120 Capsules (650 mg each)
This product is no longer sold by Raintree Nutrition, Inc. See the main product page for more information why. Try doing a google search or see the rainforest products page to find other companies selling rainforest herbal supplements or rainforest plants if you want to make this rainforest formula yourself.
A synergistic formula which combines the plants traditionally used in South America for nausea, vomiting, stomachaches, and queasy or nervous stomachs.* For more information on the individual ingredients in Stomach-Ez, follow the links provided below to the plant database files in the Tropical Plant Database.
Ingredients: A proprietary blend of ayapana, condurango, canchalgua, matico, piri-piri, and culen. To prepare this natural remedy yourself: use one part of each of the plants in the list. To make a small amount... "1 part" could be one tablespoon (you'd have 6 tablespoons of the blended herbal formula). For larger amounts, use "1 part" as one ounce or one cup or one pound. Combine all the herbs together well. The herbal mixture can then be stuffed into capsules or brewed into tea, stirred into juice or other liquid, or taken however you'd like.
Suggested Use: Take 2-3 grams twice daily or as needed. (1 gram is approximately 1/2 teaspoon)
Contraindications: Not to be used during pregnancy or while breast-feeding.
Drug Interactions: None reported.
Third-Party Published Research*
This rainforest formula has not been the subject of any clinical research. A partial listing of the published research on each herbal ingredient in the formula is shown below. Please refer to the plant database files by clicking on the plant names below to see all available documentation and research.
Ayapana (Ayapana triplinervis)
Ayapana is traditionally used in Brazilian herbal medicine for queasy stomachs, indigestion, diarrhea, fever, headaches, insomnia, nausea and vomiting, and stomach ulcers. Scientists over the years have reported that ayapana possesses analgesic, antibacterial, anticoagulant, antifungal, antiparasitic, anthelminitic, CNS depressant, and sedative actions in various animal and laboratory studies.
Kokate, C. K., et al. “Pharmacological studies on the essential oil of Eupatorium triplinerve. I. Effects on the central nervous system and antimicrobial activity.” Flavour. 1971; 2 (3): 177-180.
Jelager, L., et al. “Antibacterial and antifungal activity of medicinal plants of Mauritius.” Pharmaceutical Biol. 1998; 36:153-161.
Gupta, M., et al. “Antimicrobial activity of Eupatorium ayapana.” Fitoterapia. 2002; 73 (2):168-170.
Verpoorter, R., et al. “Medicinal plants of Surinam. IV. Antimicrobial activity of some medicinal plants.” J. Ethnopharmacol. 1987; 21: 315-318.
Condurango (Marsdenia cundurango)
In Brazilian herbal medicine condurango is used for appetite loss, dyspepsia, gastralgia, gastritis, neuralgia, stomachaches, stomach cancer, stomach ulcers, and rheumatism. Its use as a digestive aid was studied and validated in the mid-1980s when scientists reported that it increased various digestive enzymes and juices in the stomach. Other research suggests that condurango is antibacterial, anti-inflammatory, anti-leukemic, antioxidant, and antitumorous.
Yamasaki, K., et al. "Studies on the effect of crude drugs on enzyme activites (IV) Influence of stomachic crude drugs on digestive enzymes." Shoyakugaku Zasshi. 1986; 40(3): 289-294.
Ortega, T., et al. “Anti-inflammatory activity of ethanolic extracts of plants used in traditional medicine in Ecuador.” Phytother. Res. 1996: S121-S122.
Grange, J. M., et al. ”Detection of antituberculous activity in plant extracts.” J. Appl. Bacteriol. 1990; 68(6): 587-591.
Canchalagua (Schkuhria pinnata)
Canchalagua is often relied on in Peruvian herbal medicine systems to ease nausea and stomachaches, and as a general digestive aid. Scientists have reported that canchalagua has antibacterial, antifungal, anti-inflammatory, antimalarial, antispasmodic, and anti-yeast actions.
Weimann, C., et al. "Spasmolytic effects of Baccharis conferta and some of its constituents." J. Pharm. Pharmacol. 2002; 54(1): 99-104.
Bussmann, R., et al. " Minimum inhibitory concentrations of medicinal plants used in Northern Peru as antibacterial remedies." J Ethnopharmacol. 2010 October 28; 132(1): 101–108.
Wagate, C., et al. "Screening of some Kenyan medicinal plants for antibacterial activity." Phytother. Res. 2010; 24(1): 150-3.
Kassuya, C., et al. "Antipyretic and anti-inflammatory properties of the ethanolic extract, dichloromethane fraction and costunolide from Magnolia ovata (Magnoliaceae)." J. Ethnopharmacol. 2009 Jul; 124(3): 369-76.
Lim, H., et al. "Anti-inflammatory activity of pectolinarigenin and pectolinarin isolated from Cirsium chanroenicum." Biol. Pharm. Bull. 2008; 31(11): 2063-7.
Pae, H., et al. "Costunolide inhibits production of tumor necrosis factor-alpha and interleukin-6 by inducing heme oxygenase-1 in RAW264.7 macrophages." Inflamm. Res. 2007; 56(12): 520-6.
Nam, N. H. "Naturally occurring NF-KappaB inhibitors." Mini. Rev. Med. Chem. 2006; 6(8): 945-51.
De Marino, S., et al. "New sesquiterpene lactones from Laurus nobilis leaves as inhibitors of nitric oxide production." Planta Med. 2005; 71(8): 706-10.
Korhonen, R., et al. "Nitric oxide production and signaling in inflammation." Curr. Drug Targets Inflamm. Allergy. 2005 Aug; 4(4): 471-9.
Matico (Piper aduncum)
Matico is traditionally used by Indians of the Peruvian Amazon for gastritis, vomiting, fever, inflammation, diarrhea, menstrual colic, internal infections and as a postpartum tonic. Despite any scientific validation, matico still remains a main-stay in herbal medicine practices in South America for many types of digestive problems and it is quite well known and well respected for those types of conditions. In laboratory research the plant has been reported with antibacterial, anticandidal, antifungal, antileishmaniasis, antiyeast, antiviral, and cytotoxic properties.
Cde Almeida, R. R., et al. "Chemical variation in Piper aduncum and biological properties of its dillapiole-rich essential oil." Chem. Biodivers. 2009; 6(9):1427-34.
Parise-Filho, R., et al. "The anti-inflammatory activity of dillapiole and some semisynthetic analogues." Pharm Biol. 2011 Nov;49(11):1173-9.
Kloucek, P., et al. "Antibacterial screening of some Peruvian medicinal plants used in Calleria district." J. Ethnopharmacol. 2005 Jun; 99(2): 309-12.
Lentz, D. L., et al. "Antimicrobial properties of Honduran medicinal plants." J. Ethnopharmacol. 1998; 63(3): 253-263
Orjala, J., et al. "Cytotoxic and antibacterial dihydrochalcones from Piper aduncum." J. Nat. Prod. 1994; 57(1):18-26
Orjala, J., et al. "Aduncamide, a cytotoxic and antibacterial beta-phenylethylamine-derived amide from Piper aduncum." Nat. Prod. Lett. 1993; 2(3): 231-236.
Piri-Piri (Cyperus articulatus)
Piri-piri has a long history of use in herbal medicine systems in South America as a common remedy for nausea, vomiting, stomachaches, and intestinal gas throughout the continent. Piri-piri has been documented with anti-epileptic and anticonvulsant actions, as well as sedative actions in animal studies. It was also reported with antioxidant actions, antibacterial actions against Staphylococcus and Pseudo-monas, and anti-yeast actions against Candida. It passed a preliminary screening test to predict antitumor actions in other research.
Bum, E. N., et al. “Ions and amino acid analysis of Cyperus articulatus L. (Cyperaceae) extracts and the effects of the latter on oocytes expressing some receptors.” J. Ethnopharmacol. 2004 Dec; 95(2-3): 303-9.
Bum, E. N., et al. “Extracts from rhizomes of Cyperus articulatus (Cyperaceae) displace [3H]CGP39653 and [3H]glycine binding from cortical membranes and selectively inhibit NMDA receptor-mediated neurotransmission.” J. Ethnopharmacol. 1996 Nov; 54(2-3): 103-11.
Bum, E. N., et al. “Effects of Cyperus articulatus compared to effects of anticonvulsant compounds on the cortical wedge.” J. Ethnopharmacol. 2003 Jul; 87(1): 27-34.
Rakotonirina, V. S., et al. “Sedative properties of the decoction of the rhizome of Cyperus articulatus.” Fitoterapia. 2001; 72(1): 22-9.
Duarte, M., et al. "Anti-Candida activity of Brazilian medicinal plants." J Ethnopharmacol. 2005 Feb 28;97(2):305-11.
Desmarchelier, C., et al. “Studies on the cytotoxicity, antimicrobial and DNA-binding activities of plants used by the Ese'ejas.” J. Ethnopharmacol. 1996; 50(2): 91-96.
Mongelli, E., et al. “Antimicrobial activity and interaction with DNA of medicinal plants from the Peruvian Amazon region.” Rev. Argent. Microbiol. 1995 Oct-Dec; 27(4): 199-203.
Duarte, M. C., et al. “Anti-candida activity of Brazilian medicinal plants.” J. Ethnopharmacol. 2005; 97(2): 305-11.
Culen (Psoralea glandulosa)
In South American herbal medicine systems culen is traditionally used for enteritis, digestive disorders, and stomachaches among other things.*
Backhouse, C., et al. “Active constituents isolated from Psoralea glandulosa L. with antiinflammatory and antipyretic activities.” J. Ethnopharmacol. 2001; 78(1): 27-31.
Ferrandiz, M., et al. “Effect of bakuchiol on leukocyte functions and some inflammatory responses in mice.” J. Pharm. Pharmacol. 1996; 48(9): 975-980.
Backhouse, N., et al. “Antiinflammatory and antipyretic activities of Cuscuta chilensis, Cestrum parqui and Psoralea glandulosa.” Int. J. Pharmacog. 1996; 34(1): 53-57.
Erazo, S., et al. “Antimicrobial activity of Psoralea glandulosa L.” Int. J. Pharmacog. 1997; 35(5): 385-387.
Kaul, R. “Kinetics of the antistaphylococcal activity of bakuchiol in vitro.” Arzneim-Forsch. 1976; (26): 486-513.
*The statements contained herein have not been evaluated
by the Food and Drug Administration. The information contained herein is intended and provided for education, research, entertainment and information purposes only. This information is not intended to be used to diagnose, prescribe or replace proper medical care. The plants and/or formulas described herein are not intended to treat, cure, diagnose, mitigate or prevent any disease and no medical claims are made.
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Last updated 1-9-2013