Matico Leaf Powder in bulk one pound packages - Piper aduncum - Matico Leaf Powder in bulk one pound packages  - Piper angustifolium - Matico Leaf Powder in bulk one pound packages  Piper aduncum Matico Powder

Piper aduncum

This product is no longer sold by Raintree Nutrition, Inc. See the main product page for more information why. Try doing a google search or see the rainforest products page to find other companies selling rainforest herbal supplements or rainforest plants if you want to make this rainforest formula yourself.

Matico has demonstrated broad spectrum antimicrobial actions which may help to explain its long history of use for various infections and infectious diseases. In various laboratory studies over the years, matico leaves and the essential oil from the leaves or fruits have demonstrated antibacterial actions against various Gram-positive and Gram-negative bacteria. It has also been reported with actions against fungi and yeast. In addition, researchers in France reported matico had antiviral actions against polio virus. (See all cited research below.)

For more information about matico (Piper aduncum), please refer to the Database File for Matico in the Tropical Plant Database. More information can also be found in the new Antimicrobial Guide. To see pictures of matico, click here. Check out the new Discussion Forums to see if anyone is talking about how they are using this natural rainforest remedy.

Traditional Uses:* for digestive problems (vomiting, nausea, stomachaches, dyspepsia); as a carminative and stomachic to expel intestinal gas and aid digestion; as an antiseptic wound healer for cuts, scrapes, ulcers, boils, etc.; as a hemostat for internal bleeding (uterine, gastric, pulmonary); for colds, flu, coughs, bronchitis, pneumonia and other respiratory problems

Suggested Use:* This plant is best prepared as an infusion (tea): Use one teaspoon of powder for each cup of water. Pour boiling water over herb in cup and allow to steep 10 minutes. Strain tea (or allow settled powder to remain in the bottom of cup) and drink warm. It is traditionally taken in 1 cup dosages, 2-3 times daily. For more complete instrutions on preparing herbal infusions see the Methods for Preparing Herbal Remedies Page.

Contraindications: None reported.

Drug Interactions: None reported.





Third-Party Published Research*

All available third-party research on matico be found at PubMed. A partial listing of the third-party published research on matico is shown below:

Cytotoxic & Antitumor Actions:
Orjala, J., et al. “Two chromenes and a prenylated benzoic acid derivative from Piper aduncum.” Phytochemistry. 1993; 34(3): 813-818.
Orjala, J., et al. “Cytotoxic and antibacterial dihydrochalcones from Piper aduncum.” J. Nat. Prod. 1994; 57(1): 18-26.
Orjala, J., et al. “Aduncamide, a cytotoxic and antibacterial beta-phenylethylamine-derived amide from Piper aduncum.Nat. Prod. Lett. 1993; 2(3): 231-236.

Antibacterial Actions:
Orjala, J., et al. “New monoterpene-substituted dihydrochalcones from Piper aduncum.Helv. Chim. Acta 1993; 76(4): 1481-1488.
Kloucek, P., et al. “Antibacterial screening of some Peruvian medicinal plants used in Calleria district.” J. Ethnopharmacol. 2005 Jun; 99(2): 309-12.
Lemos, T. L. G., et al. “Antimicrobial activity of essential oils of Brazilian plants.” Phytother. Res. 1990; 4(2): 82-84.
Lentz, D. L., et al. “Antimicrobial properties of Honduran medicinal plants.” J. Ethnopharmacol, 1998; 63(3): 253-263.
Trillini, B., et al. “Chemical composition and antimicrobial activity of essential oil of Piper angustifolium.” Planta Med. 1996; 62(4): 372-373.
Orjala, J., et al. “Cytotoxic and antibacterial dihydrochalcones from Piper aduncum.” J. Nat. Prod. 1994; 57(1): 18-26.
Orjala, J., et al. “Three new prenylated benzoic acid derivatives and molluscicidal sesquiterpenoids from Piper aduncum leaves.” Planta Med. Suppl. 1992; 58(1) A714-.
Orjala, J., et al. “Five new prenylated p-hydroxybenzoic acid derivatives with antimicrobial and molluscicidal activity from Piper aduncum leaves.” Planta Med. 1993; 59(6): 546-551.
Orjala, J., et al. “Aduncamide, a cytotoxic and antibacterial beta-phenylethylamine-derived amide from Piper aduncum.Nat. Prod. Lett. 1993; 2(3): 231-236.

Antifungal Actions:
Cde Almeida, R. R., et al. "Chemical variation in Piper aduncum and biological properties of its dillapiole-rich essential oil." Chem. Biodivers. 2009; 6(9):1427-34.
Orjala, J., et al. “Two chromenes and a prenylated benzoic acid derivative from Piper aduncum.” Phytochemistry. 1993; 34(3): 813-818.
Lemos, T. L. G., et al. “Antimicrobial activity of essential oils of Brazilian plants.” Phytother. Res. 1990; 4(2): 82-84.
Lentz, D. L., et al. “Antimicrobial properties of Honduran medicinal plants.” J. Ethnopharmacol, 1998; 63(3): 253-263.
Trillini, B., et al. “Chemical composition and antimicrobial activity of essential oil of Piper angustifolium.” Planta Med. 1996; 62(4): 372-373.
Lago, J. H., et al. “Benzoic acid derivatives from Piper species and their fungitoxic activity against Cladosporium cladosporioides and C. sphaerospermum.J. Nat. Prod. 2004; 67(11):1783-8.
Navickiene, H., et al. “Composition and antifungal activity of essential oils from Piper aduncum, Piper arboreum and Piper tuberculatum.” Quim. Nova. 2006; 20( 3): 467-470.

Anti-Candida & Anti-yeast Actions
Braga, F. G., et al. "Antileishmanial and antifungal activity of plants used in traditional medicine in Brazil." J. Ethnopharmacol. 2007 May; 111(2): 396-402.
Lemos, T. L. G., et al. “Antimicrobial activity of essential oils of Brazilian plants.” Phytother. Res. 1990; 4(2): 82-84.
Lentz, D. L., et al. “Antimicrobial properties of Honduran medicinal plants.” J. Ethnopharmacol, 1998; 63(3): 253-263.
Trillini, B., et al. “Chemical composition and antimicrobial activity of essential oil of Piper angustifolium.” Planta Med. 1996; 62(4): 372-373.

Antiviral Actions:
Lohezic, L. E., et al. “Antiviral and cytotoxic activities of some Indonesian plants.” Fitoterapia. 2002 Aug; 73(5): 400-5.

Anti-Leishmanial & Anti-malarial Actions:
Parise-Filho, R., et al. "Dillapiole as Antileishmanial Agent: Discovery, Cytotoxic Activity and Preliminary SAR Studies of Dillapiole Analogues." Arch Pharm (Weinheim). 2012 Dec;345(12):934-44.
Valadeau, C., et al. "Medicinal plants from the Yanesha (Peru): evaluation of the leishmanicidal and antimalarial activity of selected extracts." J. Ethnopharmacol. 2009 Jun; 123(3): 413-22.
Flores, N., et al. "Antiparasitic activity of prenylated benzoic acid derivatives from Piper species." Phytochemistry. 2009; 70(5):621-7.
Braga, F. G., et al. "Antileishmanial and antifungal activity of plants used in traditional medicine in Brazil." J. Ethnopharmacol. 2007 May; 111(2): 396-402.
Torres-Santos, E. C., et al. Selective effect of 2',6'-dihydroxy-4'-methoxychalcone isolated from Piper aduncum on Leishmania amazonensis.” Antimicrob. Agents Chemother. 1999; 43(5): 1234-1241.
Torres-Santos, E. C., et al. Improvement of in vitro and in vivo antileishmanial activities of 2', 6'-dihydroxy-4'-methoxychalcone by entrapment in poly(D,L-lactide) nanoparticles.” Antimicrob. Agents Chemother. 1999; 43(7): 1776-8.

Anti-schistosomiasis, Anti-trypanosomal & Molluscicidal Actions:
Rapado, L., et al. "Molluscicidal and ovicidal activities of plant extracts of the Piperaceae on Biomphalaria glabrata (Say, 1818)." J Helminthol. 2011 Mar;85(1):66-72.
Batista, J. M. Jr, et al. "Natural chromenes and chromene derivatives as potential anti-trypanosomal agents." Biol. Pharm. Bull. 2008; 31(3): 538-40.
Orjala, J., et al. “Two chromenes and a prenylated benzoic acid derivative from Piper aduncum.” Phytochemistry. 1993; 34(3): 813-818.
Orjala, J., et al. “Three new prenylated benzoic acid derivatives and molluscicidal sesquiterpenoids from Piper aduncum leaves.” Planta Med. Suppl. 1992; 58(1) A714-.
Orjala, J., et al. “Five new prenylated p-hydroxybenzoic acid derivatives with antimicrobial and molluscicidal activity from Piper aduncum leaves.” Planta Med. 1993; 59(6): 546-551.

Insecticidal Actions:
Araujo, M., et al. "Acaricidal activity and repellency of essential oil from Piper aduncum and its components against Tetranychus urticae." Exp Appl Acarol. 2012 Jun;57(2):139-55.
Misni, N., et al. "The effect of Piper aduncum Linn. (Family: Piperaceae) essential oil as aerosol spray against Aedes aegypti (L.) and Aedes albopictus Skuse." Trop Biomed. 2011 Aug;28(2):249-58.
Misni, N., et al. "Repellency of essential oil of Piper aduncum against Aedes albopictus in the laboratory." J Am Mosq Control Assoc. 2009 Dec;25(4):442-7.
Silva, W. C., et al. "Toxicity of Piper aduncum L. (Piperales: Piperaceae) from the Amazon forest for the cattle tick Rhipicephalus (Boophilus) microplus (Acari: Ixodidae)." Vet. Parasitol. 2009; 164(2-4): 267-74.
Rafael, M. S., et al. "Potential control of Aedes aegypti (Diptera: Culicidae) with Piper aduncum L. (Piperaceae) extracts demonstrated by chromosomal biomarkers and toxic effects on interphase nuclei." Gene. Mol. Res. 2008; 7(3): 772-81.
Cde Almeida, R. R., et al. "Chemical variation in Piper aduncum and biological properties of its dillapiole-rich essential oil." Chem. Biodivers. 2009; 6(9):1427-34.
Hidayatulfathi, O., et al. “Adulticidal activity of some Malaysian plant extracts against Aedes aegypti Linnaeus.” J. Trop. Biomed. 2004 Dec; 21(2): 61-7.
Estrela, J., et al. "Toxicity of essential oils of Piper aduncum and Piper hsipidinervum against Sitophilus zeamais." Pesq. Agroped. Bras. 2006; 41(2): 217-222.

Anti-inflammatory Actions:
Parise-Filho, R., et al. "The anti-inflammatory activity of dillapiole and some semisynthetic analogues." Pharm Biol. 2011 Nov;49(11):1173-9.

Constituents Found
Rali, T., et al. "Volatile chemical constituents of Piper aduncum L and Piper gibbilimbum C. DC (Piperaceae) from Papua New Guinea." Molecules. 2007; 12(3):389-94.



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Last updated 1-2-2013