Fedegoso - Cassia occidentalis Fedegoso - Cassia occidentalis Fedegoso - Cassia occidentalis Fedegoso - Cassia occidentalis Fedegoso - Cassia occidentalis Fedegoso - Cassia occidentalis Fedegoso - Cassia occidentalis Fedegoso - Cassia occidentalis

Database File for:

Fedegoso
(Cassia occidentalis)

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FEDEGOSO

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  • Family: Leguminosae
    Genus: Cassia
    Species: occidentalis
    Synonyms: Senna occidentalis, Cassia caroliniana, C. ciliata, C. falcata, C. foetida, C. frutescens, C. geminiflora, C. linearis, C. longisiliqua, C. obliquifolia, C. planisiliqua, C. sophera, Ditremexa occidentalis
    Common names: Fedegoso, fedegosa, yerba hedionda, brusca, guanina, martinica, plata­nillo, manjerioba, peieriaba, retama, achupa poroto, heduibda, folha-de-pajé, kasiah, khiyar shember, pois piante, shih chueh ming, sinamekki, tlalhoaxin, wang chiang nan, senting, kachang kota, menting
    Parts Used: Roots, leaves, seeds


    From The Healing Power of Rainforest Herbs:

    FEDEGOSO
    HERBAL PROPERTIES AND ACTIONS
    Main Actions Other Actions Standard Dosage
  • protects liver
  • relieves pain
  • Leaves
  • detoxifies liver
  • reduces inflammation
  • Infusion: 1 cup twice daily
  • kills bacteria
  • kills cancer cells
  • Tincture: 3-4 ml twice daily
  • kills fungi
  • reduces spasms
  • Capsules: 1-2 g twice daily
  • kills parasites
  • reduces fever
  •  
  • kills viruses
  • reduces blood pressure
  •  
  • expels worms
  • kills insects
  •  
  • enhances immunity
  •    
  • cleanses blood
  •    
  • kills germs
  •    
  • detoxifies
  •    
  • promotes perspiration
  •    
  • mildly laxative
  •    

    Fedegoso is a small tree that grows 5–8 m high and is found in many tropical areas of South America, including the Amazon. Indigenous to Brazil, it is also found in warmer climates and tropical areas of South, Central, and North America. It is in the same genus as senna (C. senna) and is sometimes called “coffee senna.” It is botanically classified as both Senna occidentalis and Cassia occidentalis. Its seeds, found in long seed pods, are sometimes roasted and made into a coffee-like beverage. The Cassia genus comprises some 600 species of trees, shrubs, vines, and herbs, with numerous species growing in the South American rainforests and tropics. Many species have been used medicinally, and these tropical plants have a rich history in natural medicine. Various Cassia plants have been known since the ninth or tenth centuries as purgatives and laxatives, including Cassia angustifolia and Cassia senna.

    TRIBAL AND HERBAL MEDICINE USES

    Fedegoso has been used as natural medicine in the rainforest and other tropical areas for centuries. Its roots, leaves, flowers, and seeds have been employed in herbal medicine around the world. In Peru, the roots are considered a diuretic, and a decoction is made for fevers. The seeds are brewed into a coffee-like beverage for asthma, and a flower infusion is used for bronchitis in the Peruvian Amazon. In Brazil, the roots of fedegoso are considered a tonic, fever reducer, and diuretic; they are used for fevers, menstrual problems, tuberculosis, anemia, liver complaints, and as a tonic for general weakness and illness. The leaves are also used in Brazil for gonorrhea, fevers, urinary tract disorders, edema, and menstrual problems. The Miskito Indians of Nicaragua use a fresh plant decoction for general pain, menstrual and uterine pain, and constipation in babies. In Panama, a leaf tea is used for stomach colic, the crushed leaves are used in a poultice as an anti-inflammatory, and the crushed fresh leaves are taken internally to expel intestinal worms and parasites. In many countries around the world, the fresh and/or dried leaves of fedegoso are crushed or brewed into a tea and applied externally for skin disorders, wounds, skin fungus, parasitic skin diseases, abscesses, and as a topical analgesic and antiinflammatory natural medicine.

    PLANT CHEMICALS

    The Cassia plants are well known for a group of chemicals with strong laxative actions called anthraquinones. The most widely used species of Cassia in herbal medicine is known as senna (Cassia senna or C. acutifolia). The actions of the anthraquinones chemicals are the basis of senna’s widespread use as a purgative and strong laxative. While fedegoso does contain a small amount of these anthraquinones, it was shown in a rat study not to have the same strong purgative and laxative effects as senna.

    The main plant chemicals in fedegoso include: achrosine, aloe-emodin, anthraquinones, anthrones, apigenin, aurantiobtusin, campesterol, cassiollin, chryso-obtusin, chrysophanic acid, chrysarobin, chrysophanol, chrysoeriol, emodin, essential oils, funiculosin, galactopyranosyl, helminthosporin, islandicin, kaempferol, lignoceric acid, linoleic acid, linolenic acid, mannitol, mannopyranosyl, matteucinol, obtusifolin, obtusin, oleic acid, physcion, quercetin, rhamnosides, rhein, rubrofusarin, sitosterols, tannins, and xanthorin.

    BIOLOGICAL ACTIVITIES AND CLINICAL RESEARCH

    Fedegoso has been the subject of recent clinical research for its beneficial effects on the liver and immune system. In the late 1970s, two research groups published three studies citing the beneficial effects of fedegoso in human patients with liver toxicity, hepatitis, and even acute liver failure. Other researchers followed up on those actions, publishing four different in vivo studies (mice and rats) from 1994 to 2001. These studies report that fedegoso leaf extracts have the ability to protect the liver from various introduced chemical toxins, normalize liver enzymes and processes, and repair liver damage. Some of this research has also demonstrated significant immunostimulant activity by increasing humoral immunity and bone marrow immune cells in mice, and protecting them from chemically-induced immunosuppresion. These researchers and oers also reported the antimutagenic actions of fedegoso. In this research, fedegoso was able to prevent or reduce the mutation of healthy cells in the presence of laboratory chemicals which were known to mutate them.

    In other in vivo studies, fedegoso leaf extracts have demonstrated an anti-inflammatory, hypotensive, smooth-muscle relaxant, antispasmodic, weak uterine stimulant, vasoconstrictor, and antioxidant activities in laboratory animals. These documented actions certainly help to explain its uses in traditional medicine systems for menstrual cramps and other internal inflammatory conditions. Fedegoso has also been used for many types of bacterial, fungal, and parasitic infections for many years in the tropical countries where it grows. In vitro clinical research on fedegoso leaves over the years has reported active antibacterial, antifungal, antiparasitic, insecticidal, and antimalarial properties.

    CURRENT PRACTICAL USES

    Although the seeds of fedegoso are used in herbal medicine in small amounts (and even roasted and brewed as a coffee substitute in some countries), several clinical studies have demonstrated the toxicity of the fresh and/or dried/roasted seeds. Ingestion of large amounts of the seeds by grazing animals has been reported to cause toxicity problems and even death in cows, horses, and goats. Due to the well-known and well-documented toxicity of these seeds, they are best avoided altogether. Toxicity studies on the aerial parts, leaves, and roots of fedegoso have been published by several research groups. These studies reported that various leaf and root extracts given to mice (administered orally and injected at up to 500 mg/kg) did not demonstrate any toxic effect or cause mortality.

    Health practitioners today are employing fedegoso in their practices much the same way it has been in traditional medicine for many years. It is an excellent natural remedy for bacterial and fungal infections and now is clinically shown to boost immune function simultaneously. As a liver tonic, science supports its beneficial action and use in various liver conditions including anemia, hepatitis, and liver damage (drug- or alcohol-induced). New research suggests, with its antimutagenic actions, fedegoso could possibly help keep damaged liver cells from turning into cancerous ones, as often happens with chronic hepatitis B and C infections.



    FEDEGOSO PLANT SUMMARY
    Main Preparation Method: infusion

    Main Actions (in order):
    antimicrobial, antihepatotoxic (liver detoxifier), hepatotonic (tones, balances, strengthens the liver), antiparasitic, immune stimulant

    Main Uses:

    1. as a broad-spectrum internal and external antimicrobial to treat bacterial and fungal infections
    2. for liver disorders (jaundice, hepatitis, cirrhosis, anemia, detoxification, injury/failure, bile stimulant, etc)
    3. for intestinal worms, internal parasites, skin parasites
    4. as an immune stimulant
    5. as a cellular protector and a preventative to cell damage (immune, liver, kidney, cancer preventative)
    Properties/Actions Documented by Research:
    anti-inflammatory, antibacterial, antifungal, antihepatotoxic (liver detoxifier), antimalarial, antimutagenic (cellular protector), antioxidant, antiparasitic, antispasmodic, aperient (mild laxative), hepatoprotective (liver protector), hepatotonic (tones, balances, strengthens the liver), hypotensive (lowers blood pressure), immune stimulant, insecticidal, muscle relaxant, weak uterine stimulant, vasoconstrictor

    Other Properties/Actions Documented by Traditional Use:
    analgesic (pain-reliever), anticancerous, antihemorrhagic (reduces bleeding), antiseptic, astringent, antiviral, bile stimulant, blood cleanser, cardiotonic (tones, balances, strengthens the heart), contraceptive, detoxifier, diaphoretic (promotes sweating), digestive stimulant, diuretic, febrifuge (reduces fever), menstrual stimulant, tonic (tones, balances, strengthens overall body functions), vermifuge (expels worms)

    Cautions: May speed the clearance of some drugs in the liver (thereby reducing their effect). It is mildly hypotensive (lowers blood pressure).



    Traditional Preparation: The therapeutic dosage is reported to be 1 cup of a standard leaf infusion twice daily. If desired, 3–4 ml of a tincture twice daily or 1–2 g in tablets or capsules twice daily can be substituted. See Traditional Herbal Remedies Preparation Methods page if necessary for definitions.

    Contraindications:

    • Fedegoso leaf extracts have demonstrated weak uterine stimulant activity and smooth-muscle relaxant actions in rats. As such, the use of this plant is contraindicated during pregnancy.
    • Fedegoso has demonstrated hypotensive activity in dogs and, as such, is probably contraindicated in people with low blood pressure. Individuals taking medications to lower their blood pressure should check with their doctor first before taking fedegoso (and monitor their blood pressure accordingly, as medications may need to be adjusted).
    • Long-term ingestion of small amounts and single high dosages of fedegoso seeds cause toxic reactions including myodegeneration and death. Do not use fedegoso seeds without the supervision of a qualified professional who is familiar with the mechanisms, chemicals, actions, and toxicity of these seeds.

    Drug Interactions: It may potentiate the effects of antihypertensive drugs. Fedegoso has demonstrated significant antihepatotoxic (liver protective), hepatotonic (liver tonic), and hepatic detoxification (liver detoxifing) effects in animal and human studies. As such, the use of this plant might interfere with the metabolism of some drugs in the liver by increasing the clearance of them and/or reducing their half-life (which may reduce the effects of those drugs that require metabolization in the liver).



    WORLDWIDE ETHNOMEDICAL USES
    Africa for abscesses, bile complaints, birth control, bronchitis, bruises, cataracts, childbirth, constipation, dysentery, edema, erysipelas, eye infections, fainting, fever, gonorrhea, guinea worms, headache, hematuria, hemorrhages (pregnancy), hernia, increasing perspiration, inflammation, itch, jaundice, kidney infections, leprosy, malaria, pain (kidney), menstrual disorders, rheumatism, ringworms, scabies, skin diseases, skin parasites, sore throat, stomach ulcers, stomachache, swelling, syphilis, tetanus, worms, water retention, wounds
    Amazonia for abdominal pain, birth control, bile insufficiency, malaria
    Brazil for anemia, constipation, edema, fatigue, fever, gonorrhea, liver disorders, malaria, menstrual disorders, skin problems, tuberculosis, urinary disorders, water retention, weakness
    Central America for abortions, antifungal, athlete's foot, birth control, constipation, diarrhea, fungal infections, headache, menstrual disorders, menstrual pain, pain, respiratory infections, ringworm, spasms, uterine pain, urinary tract infections, urinary insufficiency, worms
    Haiti for acne, asthma, burns, colic, constipation, dropsy, eye infections, gonorrhea, headache, malaria, rheumatism, skin rashes and infections, and to increase perspiration
    India for abscesses, bites (scorpion), constipation, diabetes, edema, fever, inflammation, itch, liver diseases, liver support, rheumatism, ringworm, scabies, skin diseases, snakebite, wounds
    Mexico for chills, digestive sluggishness, dyspepsia, earache, eczema, edema, fatigue, fever, headache, inflammation (skin), laxative, leprosy, nausea, pain, rash, rheumatism, ringworms, skin problems, sores, stomachache, swelling, tumors, ulcers, venereal disease, water retention, worms, yellow fever
    Panama for colic, inflammation, spasms, stomach problems, worms, and as an antiseptic
    Peru for asthma, bronchitis, fever, liver problems, urinary insufficiency
    Trinidad for abortions, childbirth, colds, constipation, heart problems, inflammation, liver problems, palpitations
    Venezuela for asthma, colds, fever, intestinal gas, malaria, menstrual difficulties, skin problems, water retention
    Elsewhere for abdominal pain, abortions, bile insufficiency, birth control, bites (scorpion), childbirth, constipation, dermatosis, digestive problems, eczema, edema, eye infections, fevers, gonorrhea, headache, hemoglobin disorders, hemorrhage, hypertension, laxative, lice, liver, malaria, menstrual disorders, pain, parasites, rheumatism, ringworms, scabies, skin disorders, snakebite, spasms, urinary insufficiency, worms, yellow fever



    The above text has been printed from The Healing Power of Rainforest Herbs by Leslie Taylor, copyrighted © 2005
    All rights reserved. No part of this document may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, recording, or by any information storage or retrieval system, including websites, without written permission

    † The statements contained herein have not been evaluated by the Food and Drug Administration. The information contained in this plant database file is intended for education, entertainment and information purposes only. This information is not intended to be used to diagnose, prescribe or replace proper medical care. The plant described herein is not intended to treat, cure, diagnose, mitigate or prevent any disease. Please refer to our Conditions of Use for using this plant database file and web site.




    Third-Party Research on Fedegoso

    All available third-party research on fedegoso can be found at PubMed. A partial listing of the third-party published research on fedegoso is shown below:

    Antimicrobial Actions:
    Bhagat, M., et al. "Evaluation of Cassia occidentalis for in vitro cytotoxicity against human cancer cell lines and antibacterial activity." Indian J Pharmacol. 2010 Aug;42(4):234-7.
    Li, S., et al. "Cycloartane triterpenoids from Cassia occidentalis." Planta Med. 2012 May;78(8):821-7.
    Evans CE, et al. “Efficacy of some nupe medicinal plants against Salmonella typhi: an in vitro study.” J. Ethnopharmacol. 2002 Apr; 80(1): 21-4.
    Samy, R. P., et al. “Antibacterial activity of some folklore medicinal plants used by tribals in Western Ghats of India.” J. Ethnopharmacol. 2000; 69(1): 63–71.
    Anesini, C., et al. “Screening of plants used in Argentine folk medicine for antimicrobial activity.” J. Ethnopharmacol. 1993; 39(2): 119–28.
    Caceres, A., et al. “Plants used in Guatemala for the treatment of dermatophytic infections. 1. Screening for antimycotic activity of 44 plant extracts.” J. Ethnopharmacol. 1991; 31(3): 263–76.
    Hussain, H., et al. “Plants in Kano ethomedicine: screening for antimicrobial activity and alkaloids.” Int. J. Pharmacog. 1991; 29(1): 51–6.
    Gaind, K. N., et al. “Antibiotic activity of Cassia occidentalis.” Indian J. Pharmacy 1966; 28(9): 248–50.

    Immunostimulant Actions:
    Bin-Hafeez, B., et al. “Protective effect of Cassia occidentalis L. on cyclophosphamide-induced suppression of humoral immunity in mice.” J. Ethnopharmacol. 2001; 75(1): 13–18.

    Antioxidant Actions:
    Arya, V., et al. "Antioxidant activity of organic and aqueous leaf extracts of Cassia occidentalis L. in relation to their phenolic content." Nat Prod Res. 2011 Sep;25(15):1473-9.
    El-Hashash M., et al. "Antioxidant properties of methanolic extracts of the leaves of seven Egyptian Cassia species." Acta Pharm. 2010 Sep;60(3):361-7.
    Sreejith, G., et al. "Anti-allergic, anti-inflammatory and anti-lipidperoxidant effects of Cassia occidentalis Linn." Indian J Exp Biol. 2010 May;48(5):494-8.

    Liver Protective & Detoxification Actions:
    Yadav, J., et al. "Cassia occidentalis L.: a review on its ethnobotany, phytochemical and pharmacological profile." Fitoterapia. 2010 Jun;81(4):223-30.
    Jafri, M. A., et al. “Hepatoprotective activity of leaves of Cassia occidentalis against paracetamol and ethyl alcohol intoxication in rats.” J. Ethnopharmacol. 1999; 66(3): 355–61.
    Sharma, N., et al. “Protective effect of Cassia occidentalis extract on chemical-induced chromosomal aberrations in mice.” Drug Chem. Toxicol. 1999; 22(4): 643–53.
    Saraf, S., et al. “Antiheptatotoxic activity of Cassia occidentalis.” Int. J. Pharmacog. 1994; 32(2): 178–83.
    Subbarao, V. V., et al. “Changes in serum transaminases due to hepatotoxicity and the role of an indigenous hepatotonic, LIV-52.” Probe 1978; 17(2): 175–78.
    Sethi, J. P., et al. “Clinical management of severe acute hepatic failure with special reference to LIV-52 in therapy.” Probe 1978; 17(2): 155–58.
    Sama, S., et al. “Efficacy of an indigenous compound preparation (LIV-52) in acute viral hepatitis—A double blind study.” Indian J. Med. Res. 1976; 64: 738.

    Skin Repigmentation Actions (Vitiligo):
    Babitha, S., et al. "A stimulatory effect of Cassia occidentalis on melanoblast differentiation and migration." Arch Dermatol Res. 2011 Apr;303(3):211-6.

    Antidiabetic Actions:
    Verma, L., et al. "Antidiabetic activity of Cassia occidentalis (Linn) in normal and alloxan-induced diabetic rats." Indian J Pharmacol. 2010 Aug;42(4):224-8.
    Verma, L., et al. "Effect of ethanolic extract of Cassia occidentalis Linn. for the management of alloxan-induced diabetic rats." Pharmacognosy Res. 2010 May;2(3):132-7.

    Antimutagenic (cancer preventative) and Anticancerous Actions:
    Bhagat, M., et al. "Evaluation of Cassia occidentalis for in vitro cytotoxicity against human cancer cell lines and antibacterial activity." Indian J Pharmacol. 2010 Aug;42(4):234-7.
    Yadav, J., et al. "Cassia occidentalis L.: a review on its ethnobotany, phytochemical and pharmacological profile." Fitoterapia. 2010 Jun;81(4):223-30.
    Bin-Hafeez, B., et al. “Protective effect of Cassia occidentalis L. on cyclophosphamide-induced suppression of humoral immunity in mice.” J. Ethnopharmacol. 2001; 75(1): 13–18.
    Sharma, N., et al. “In vitro inhibition of carcinogen-induced mutagenicity by Cassia occidentalis and Emblica officinalis.” Drug Chem. Toxicol. 2000; 23(3): 477–84.
    Sharma, N., et al. “Protective effect of Cassia occidentalis extract on chemical-induced chromosomal aberrations in mice.” Drug Chem. Toxicol. 1999; 22(4): 643–53.

    Laxative Actions:
    Elujoba, A., et al. “Chemical and biological analyses of Nigerian Cassia species for laxative activity.” J. Pharm. Biomed. Anal. 1989; 7(12): 1453–57.

    Anti-inflammatory, Muscle Relaxant & Antispasmodic Actions:
    Irié-N'guessan, G., et al. "Tracheal relaxation of five Ivorian anti-asthmatic plants: role of epithelium and K^(+) channels in the effect of the aqueous-alcoholic extract of Dichrostachys cinerea root bark." J Ethnopharmacol. 2011 Nov 18;138(2):432-8.
    Sreejith, G., et al. "Anti-allergic, anti-inflammatory and anti-lipidperoxidant effects of Cassia occidentalis Linn." Indian J Exp Biol. 2010 May;48(5):494-8.
    Sadique, J., et al. “Biochemical modes of action of Cassia occidentalis and Cardiospermum halicacabum in inflammation.” J. Ethnopharmacol. 1987; 19(2): 201–12.
    Feng, P., et al. “Pharmacological screening of some West Indian medicinal plants.” J. Pharm. Pharmacol. 1962; 14: 556–61.

    Antimalarial, Antiparasitic & Insecticidal Actions:
    Panneerselvam, C., et al. "Adulticidal, repellent, and ovicidal properties of indigenous plant extracts against the malarial vector, Anopheles stephensi (Diptera: Culicidae)." Parasitol Res. 2012 Nov 29.
    Kumar, S., et al. "Evaluation of 15 Local Plant Species as Larvicidal Agents Against an Indian Strain of Dengue Fever Mosquito, Aedes aegypti L. (Diptera: Culicidae)." Front Physiol. 2012;3:104.
    Kundu, S., et al. "In vitro screening for cestocidal activity of three species of Cassia plants against the tapeworm Raillietina tetragona." J Helminthol. 2012 Mar 20:1-6.
    Equale, T., et al. "In vitro anthelmintic activity of crude extracts of five medicinal plants against egg-hatching and larval development of Haemonchus contortus." J Ethnopharmacol. 2011 Sep 1;137(1):108-13.
    Ibrahim, M., et al. "Senna occidentalis leaf extract possesses antitrypanosomal activity and ameliorates the trypanosome-induced anemia and organ damage." Pharmacognosy Res. 2010 May;2(3):175-80.
    Tona, L., et al. “In vitro antiplasmodial activity of extracts and fractions from seven medicinal plants used in the Democratic Republic of Congo.” J. Ethnopharmacol. 2004 Jul; 93(1): 27-32.
    Tona, L., et al. “In-vivo antimalarial activity of Cassia occidentalis, Morinda morindoides and Phyllanthus niruri.” Ann. Trop. Med. Parasitol. 2001; 95(1): 47–57.
    Gasquet, M., et al. “Evaluation in vitro and in vivo of a traditional antimalarial, ‘Malarial 5.’” Fitoterapia 1993; 64(5): 423.
    Schmeda-Hirschmann, G., et al. “A screening method for natural products on triatomine bugs.” Phytother. Res. 1989; 6(2): 68–73.

    Non-Toxic Actions:
    Silva, M., et al. "Acute and subacute toxicity of Cassia occidentalis L. stem and leaf in Wistar rats." J Ethnopharmacol. 2011 Jun 22;136(2):341-6.

    Yadav, J., et al. "Cassia occidentalis L.: a review on its ethnobotany, phytochemical and pharmacological profile." Fitoterapia. 2010 Jun;81(4):223-30.

    Toxic Actions in Pregnancy:
    Aragão, T., et al., "Toxicological reproductive study of Cassia occidentalis L. in female Wistar rats." J Ethnopharmacol. 2009 May 4;123(1):163-6.




    * The statements contained herein have not been evaluated by the Food and Drug Administration. The information contained in this plant database file is intended for education, entertainment and information purposes only. This information is not intended to be used to diagnose, prescribe or replace proper medical care. The plant described herein is not intended to treat, cure, diagnose, mitigate or prevent any disease. Please refer to our Conditions of Use for using this plant database file and web site.




    © Copyrighted 1996 to present by Leslie Taylor, Milam County, TX 77857.
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    Last updated 12-28-2012