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A synergistic formula of 8 rainforest botanicals traditionally used in South America for hypertension.* For more information on the individual ingredients in Amazon Heart Support, follow the links provided below to the plant database files in the Tropical Plant Database.

Ingredients: A proprietary blend of Brazilian peppertree, abuta, chanca piedra, picão preto, erva tostão, mulungu, graviola, and mutamba. To prepare this natural remedy yourself: use two parts abuta, two parts Brazilian peppertree and 1 part each of the remaining herbs in the list. To make a small amount... "1 part" could be one tablespoon (you'd have 10 tablespoons of the blended herbal formula). For larger amounts, use "1 part" as one ounce or one cup or one pound. Combine all the herbs together well. The herbal mixture can then be stuffed into capsules or brewed into tea, stirred into juice or other liquid, or taken however you'd like.

Suggested Use: Take 1-2 grams (by weight) twice daily or 1/2 to 1 teaspoon (by volume) twice daily.
Contraindications: Not to be used during pregnancy or while breast-feeding.
Drug Interactions: May enhance the effect of diuretic, ACE-inhibitor, antihypertensive and cardiac depressant medications.
Other Practitioner Observations:
1. Plants in this formula have been documented to reduce blood pressure. This product is contraindicated for persons with low blood pressure.
2. Several plants in this formula have various actions on heart function, including reducing heart rate and having a cardiac depressant effect. Those with bradycardia, or those on medications to depress heart function and heart rate should be monitored more closely on this formula.
3. Several plants in this formula have demonstrated a hypoglycemic effect in animals. Those individuals with hypoglycemia should monitor their blood sugar levels for this possible effect.

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Third-Party Published Research*

This rainforest formula has not been the subject of any clinical research. A partial listing of third-party published research on each herbal ingredient in the formula is shown below. Please refer to the plant database files by clicking on the plant names below to see all available documentation and research on each plant ingredient.

Brazilian Peppertree (Schinus molle)
Bello, R., et al. "Effects on arterial blood pressure of the methanol and dichloromethanol extracts from Schinus molle L. in rats." Phytother. Res. 1996; 10(7): 634-35.
Hayashi, T., et al. "Pentagalloylglucose, a xanthine oxidase inhibitor from a Paraguayan crude drug, "Molle-i" (Schinus terebinthifolius)." J. Nat. Prod. 1989 Jan-Feb; 52(1): 210-1.
Marzouk, M.S., et al. "Antioxidant flavonol glycosides from Schinus molle." Phytother. Res. 2006 Mar; 20(3): 200-5.
Zaidi, S., et al. "Some preliminary studies of the pharmacological activities of Schinus molle." Pak. J. Sci. Ind. Res. 1970; 13: 53.
Bello, R., et al. "In vitro pharmacological evaluation of the dichloromethanol extract from Schinus molle L." Phytother. Res. 1998; 12(7): 523-25.
Barrachina, M. "Analgesic and central depressor effects of the dichloromethanol extract from Schinus molle L." Phytother. Res. 1997; 11(4): 317-19.
Jain, M. K., et al. "Specific competitive inhibitor of secreted phospholipase A2 from berries of Schinus terebinthifolius." Phytochemistry 1995; 39(3): 537-47.

Abuta (Cissampelos pareira)
Yao, W. X., et al. "Effects of tetrandrine on cardiovascular electrophysiologic properties." Act. Pharmacol. Sin. 2002; 23(12): 1069-74.
Mokkhasmit, M., et al. "Study on toxicity of Thai medicinal plants." Dept. Med. Sci. 1971; 12(2/4): 36-65.
Feng, P. C., et al. "Pharmacological screening of some West Indian medicinal plants." J. Pharm. Pharmacol. 1962; 14: 556-61.
Mokkhasmit, M., et al. "Pharmacological evaluation of Thai medicinal plants continued." J. Med. Ass. Thailand 1971; 54(7): 490-504.
Caceres, A., et al. "Diuretic activity of plants used for the treatment of urinary ailments in Guatemala." J. Ethnopharmacol. 1987; 19(3): 233-45.

Chanca Piedra (Phyllanthus niruri)
Iizuka, T,, et al. "Inhibitory effects of methyl brevifolincarboxylate isolated from Phyllanthus niruri L. on platelet aggregation." Biol. Pharm. Bull. 2007; 30(2): 382-4.
Iizuka, T., et al. "Vasorelaxant Effects of Methyl Brevifolincarboxylate from the Leaves of Phyllanthus niruri." Biol. Pharm. Bull. 2006; 29(1): 177-9.
Srividya, N., et al. "Diuretic, hypotensive and hypoglycaemic effect of Phyllanthus amarus." Indian J. Exp. Biol. 1995; 33(11): 861-64.
Shimizu, M., et al. "Studies on aldose reductase inhibitors from natural products. II. Active components of a Paraguayan crude drug, ‘paraparai mi,’ Phyllanthus niruri." Chem. Pharm. Bull. (Tokyo) 1989; 37(9): 2531-32.
Adeneye, A., et al. "Hypoglycemic and hypocholesterolemic activities of the aqueous leaf and seed extract of Phyllanthus amarus in mice." Fitoterapia. 2006 Dec; 77(7-8): 511-4.

Picão Preto (Bidens pilosa)
Nguelefack, T. B., et al. "Relaxant effects of the neutral extract of the leaves of Bidens pilosa Linn on isolated rat vascular smooth muscle." Phytother. Res. 2005; 19(3): 207-10.  
Dimo, T., et al. "Leaf methanol extract of Bidens pilosa prevents and attenuates the hypertension induced by high-fructose diet in Wister rats." J. Ethnopharmacol. 2002; 83(3): 183-91.
Dimo, T., et al. "Effects of the aqueous and methylene chloride extracts of Bidens pilosa leaf on fructose-hypertensive rats." J. Ethnopharmacol. 2001; 76(3): 215-21.
Dimo, T., et al. "Hypotensive effects of a methanol extract from Bidens pilosa Linn. on hypertensive rats." C. R. Acad. Sci. Paris 1999; 322(4): 323-29.
Dimo, T., et al. "Effects of leaf aqueous extract of Bidens pilosa (Asteraceae) on KCL- and norepinephrine-induced contractions of rat aorta." J. Ethnopharmacol. 1998; 60(2): 179-82.

Erva Tostão (Boerhaavia diffusa)
Hansen, K., et al. "In vitro screening of traditional medicines for anti-hypertensive effect based on inhibition of the angiotensin converting enzyme (ACE)." Ethnopharmacol. 1995; 48(1): 43-51.
Lami, N., et al. "Constituents of the roots of Boerhaavia diffusa L. III. Identification of Ca2+ channel antagonistic compound from the methanol extract." Chem. Pharm. Bull. 1991; 39(6): 1551-5.
Ramabhimaiah, S., et al. "Pharmacological investigations on the water soluble fraction of methanol extract of Boerhaavia diffusa root." Indian Drugs 1984; 21(8): 343-44.
Gaitonde, B. B., et al. "Diuretic activity of punarnava (Boerhaavia diffusa)." Bull. Haffkine Inst. 1974; 2: 24.
Chowdhury, A., et al. "Boerhaavia diffusa: effect on diuresis and some renal enzymes." Ann. Biochem. Exp. Med. 1955; 15: 119-26.
Singh, R. P., et al. "Recent approach in clinical and experimental evaluation of diuretic action of punarnava (B. diffusa) with special reference to nephrotic syndrome." J. Res. Edu. Ind. Med. 1955; 7(1): 29-35.

Mulungu (Erythrina mulungu, crista-galli)
Vasconcelos, S. M., et al. "Central activity of hydroalcoholic extracts from Erythrina velutina and Erythrina mulungu in mice." J. Pharm. Pharmacol. 2004; 56(3): 389-93.
Vasconcelos, S. M., et al. "Antinociceptive activities of the hydroalcoholic extracts from Erythrina velutina and Erythrina mulungu in mice." Biol. Pharm. Bull. 2003; 26(7): 946-9.
Njamen, D., et al. "Anti-inflammatory activity of erycristagallin, a pterocarpene from Erythrina mildbraedii."
Eur. J. Pharmacol. 2003 May; 468(1): 67-74.

Graviola (Annona muricata)
Carbajal, D., et al. "Pharmacological screening of plant decoctions commonly used in Cuban folk medicine." J. Ethnopharmacol. 1991; 33(1/2): 21-4.
Feng, P. C., et al. "Pharmacological screening of some West Indian medicinal plants." J. Pharm. Pharmacol. 1962; 14: 556-61.
Meyer, T. M. "The alkaloids of Annona muricata." Ing. Ned. Indie. 1941; 8(6): 64.
N’gouemo, P., et al. "Effects of ethanol extract of Annona muricata on pentylenetetrazol-induced convulsive seizures in mice." Phytother. Res. 1997; 11(3): 243-45.
Padma, P., et al. "Effect of alcohol extract of Annona muricata on cold immobilization stress induced tissue lipid peroxidation." Phytother. Res. 1997; 11(4): 326-327.

Mutamba (Guazuma ulmifolia)
Caballero-George, C., et al. "In vitro inhibition of [3H]-angiotensin II binding on the human AT1 receptor by proanthocyanidins from Guazuma ulmifolia bark." Planta Med. 2002; 68(12): 1066-71.
Saito, A., et al. "Systematic synthesis of galloyl-substituted procyanidin B1 and B2, and their ability of DPPH radical scavenging activity and inhibitory activity of DNA polymerases." Bioorg. Med. Chem. 2005 Apr; 13(8): 2759-71.
Hor, M., et al. "Proanthocyanidin polymers with antisecretory activity and proanthocyanidin oligomers from Guazuma ulmifolia bark." Phytochemistry. 1996; 42(1): 109-19.
Barros, G. S. G., et al. "Pharmacological screening of some Brazilian plants." J. Pharm. Pharmacol. 1970; 22: 116.

*This is an informational site only and no products are sold. The statements contained herein have not been evaluated by the Food and Drug Administration. The information contained in this plant database file is intended for education, entertainment and information purposes only. This information is not intended to be used to diagnose, prescribe or replace proper medical care. The plant described herein is not intended to treat, cure, diagnose, mitigate or prevent any disease. Please refer to our Conditions of Usefor using this plant database file and web site.