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Espinheira Santa Powder Maytenus ilicifolia1 Pound (16 oz) Buy Now
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Purchase a one pound package of Raintree's sustainably harvested pure espinheira santa leaf powder (Maytenus ilicifolia) - rich in active and beneficial phytochemicals that occur naturally in this plant. Espinheira santa contains a group of well known plant chemicals called maytansinoids including two important chemicals named maytansine and maytanprine. These plant chemicals have been studied since the early 1970's for their active biological properties and uses.* This plant has been milled into a fine powder which is suitable to stuff into capsules or to prepare your own teas, tinctures or extracts. Raintree's espinheira santa has been sustainably wild-harvested in the Amazon Rainforest (without any pesticides or fertilizers). To see pictures of this plant, click here.
Traditional Uses:* for cancer (melanoma, carcinoma, adenocarcinoma, lymphoma, leukemia); for stomach disorders (ulcers, acid reflux, gastritis, dyspepsia, indigestion, and to tone, balance, and strengthen the gastric tract); as a menstrual stimulant and for estrogen hormonal balancing during menopause; for adrenal exhaustion and to support adrenal function; for detoxification (skin, blood, kidney, stomach, adrenals)
For more information about espinheira santa (Maytenus ilicifolia), please refer to the Database File for Espinheira Santa in the Tropical Plant Database. For general information on Raintree's available bulk plants and sustainable harvesting practices, please refer to Main Page for Bulk Plants.
This bulk one pound package retails for $25.00.
Purchase Espinheira Santa Powder Now
Print a PDF Espinheira Santa Brochure
Ingredients: 100% pure espinheira santa (Maytenus ilicifolia) leaves. No binders, fillers or additives are used. This product is non-irradiated and non-fumigated. It is a wild harvested product—grown naturally in the Brazilian Amazon without any pesticides or fertilizers.
Suggested Use: This plant is best prepared as an infusion (tea): Use one teaspoon of powder for each cup of water. Pour boiling water over herb in cup and allow to steep 10 minutes. Strain tea (or allow settled powder to remain in the bottom of cup) and drink warm. It is traditionally taken in ½ to 1 cup dosages, 2-3 times daily. For more complete instructions on preparing herbal infusions see the Methods for Preparing Herbal Remedies Page.
Contraindications:
- Animal studies suggests that water extracts of espinheira santa may have estrogenic effects and reduce fertility in females. Women seeking treatment for infertility, attempting to get pregnant, or those with estrogen positive cancers should not use this plant.
Drug Interactions: None reported.
RELATED PRODUCTS:
Espinheira santa can be found as an ingredient in these proprietary Raintree formulas:
Espinheira Santa Tech Report -- A Technical Plant Data Report is available for espinheira santa.
Third-Party Published Research:*
This Raintree product has not been the subject of any clinical research. All available third-party research on espinheira santa be found at PubMed/Medline. A partial listing of the third-party published research on espinheira santa is shown below:
Anticancerous & Antileukemic Actions:
Liu Z, et al. “Metabolism studies of the anti-tumor agent maytansine and its analog ansamitocin P-3 using liquid
chromatography/tandem mass spectrometry.” J. Mass. Spectrom. 2005; 40(3): 389-99.
Nakao, H., et al. “Cytotoxic activity of maytanprine isolated from Maytenus diversifolia in human leukemia K562
cells.” Biol. Pharm. Bull. 2004; 27(8): 1236-40.
Cassady, J. M., et al. “Recent developments in the maytansinoid antitumor agents.” Chem. Pharm. Bull. 2004;
52(1): 1-26.
Ohsaki, A., et al. “Four new triterpenoids from Maytenus ilicifolia.” J. Nat. Prod. 2004; 67(3): 469-71.
Horn, R. C., et al. “Antimutagenic activity of extracts of natural substances in the Salmonella/microsome
assay.” Mutagenesis. 2003 Mar; 18(2): 113-8.
Buffa Filho, W., et al. “Quantitative determination for cytotoxic Friedo-nor-oleanane derivatives from five
morphological types of Maytenus ilicifolia (Celastraceae) by reverse-phase high-performance liquid
chromatography.” Phytochem. Anal. 2002 Mar-Apr; 13(2): 75-8.
Miura, N. et al. “Protective effects of triterpene compounds against the cytotoxicity of cadmium in HepG2 cells.”
Mol. Pharm. 1999; 56(6); 1324–28.
Liu, C., et al. “Eradication of large colon tumor xenografts by targeted delivery of maytansinoids.” Proc. Natl.
Acad. Sci. 1996 Aug; 93(16): 8618-23.
Shirota, O., et al. “Cytotoxic aromatic triterpenes from Maytenus ilicifolia and Maytenus chuchuhuasca.” J. Nat.
Prod. 1994; 57(12): 1675–81.
Itokawa, H., et al. “Cangorins F–J, five additional oligo-nicotinated sesquiterpene polyesters from Maytenus
ilicifolia." J. Nat. Prod. 1994; 57(4): 460–70.
Arisawa, M., et al. “Cell growth inhibition of KB cells by plant extracts.” Natural Med. 1994; 48(4): 338–347.
Itokawa, H., et al. “Oligo-nicotinated sesquiterpene polyesters from Maytenus ilicifolia." J. Nat. Prod. 1993;
56(9); 1479–1485.
Itokawa, H., et al. “Antitumor substances from South American plants.” Pharmacobio. Dyn. 1992; 15(1): S
Fox, B. W. “Medicinal plants in tropical medicine. 2. Natural products in cancer treatment from bench to the
clinic.” Trans. R. Soc. Trop. Med. Hyg. 1991; 85(1): 22-5.
Ravry, M. J., et al. “Phase II evaluation of maytansine (NSC 153858) in advanced cancer. A Southeastern
Cancer Study Group trial.” Am. J. Clin. Oncol. 1985 Apr; 8(2): 148-50.
Suffnes, M. J., et al. “Current status of the NCI plant and animal product program.” J. Nat. Prod. 1982; 45:
1–14.
Cabanillas, F., et al. “Phase I study of maytansine using a 3-day schedule.” Cancer Treatment Reports. 1976;
(60): 1127–39.
Chabner, B. A., et al. “Initial clinical trials of mayansine, an antitumor plant alkaloid.” Cancer Treatment
Reports. 1978; (62): 429–33.
O'Connell, M. J., et al. “Phase II trial of maytansine in patients with advanced colorectal carcinoma.” Cancer
Treatment Reports. 1978 (62); 1237-38.
Wolpert-Defillipes, M. K., et al. “Initial studies on the cytotoxic action of maytansine, a novel ansa macrolide.”
Biochemical Pharmacology. 1975; 24: 751–54.
Melo, A. M., et al. “First observations on the topical use of primin, plumbagin and maytenin in patients with skin
cancer.” Rev. Inst. Antibiot. 1974 Dec.
Monache, F. D., et al., “Maitenin: A new antitumoral substance from Maytenus sp.” Gazetta Chimica Italiana
1972; 102: 317–20.
de Santana, C. F., et al. “Primeiras observacoes sobre o emprego da maitenina em pacientes cancerosos.”
Rev. Inst. Antibiot. 1971; 11: 37–49.
Hartwell, J. L. “Plants used against cancer: A survey.” Lloydia. 1968; 31: 114.
Anti-ulcer & Antacid Actions:
Cipriani, T. R., et al. "A polysaccharide from a tea (infusion) of Maytenus ilicifolia leaves with anti-ulcer protective effects." J. Nat. Prod. 2006; 69(7):1018-21.
Ferreira, P. M., et al. “A lyophilized aqueous extract of Maytenus ilicifolia leaves inhibits histamine-mediated
acid secretion in isolated frog gastric mucosa.” Planta Med. 2004 Jun; 219(2): 319-24.
Jorge, R. M., et al. “Evaluation of antinociceptive, anti-inflammatory and antiulcerogenic activities of Maytenus
ilicifolia.” J. Ethnopharmacol. 2004 Sep; 94(1): 93-100.
Tabach, R., et al. “Evaluation of the anti-ulcerogenic activity of a dry extract of Maytenus ilicifolia Martius ex.
Reiss produced by a jet spouted bed dryer.” Pharmazie. 2003 Aug; 58(8): 573-6.
Leite, J. P., et al. “Isolation and HPLC quantitative analysis of flavonoid glycosides from Brazilian beverages (Maytenus ilicifolia and M. aquifolium).” J. Agric. Food Chem. 2001; 49(8): 3796-801.
Queiroga, C. L., et al. “Evaluation of the antiulcerogenic activity of friedelan-3beta-ol and friedelin isolated from Maytenus ilicifolia (Celastraceae).”J. Ethnopharmacol. 2000 Oct; 72(3): 465-8.
Souza-Formigoni, M. L., et al. “Antiulcerogenic effects of two Maytenus species in laboratory animals.” J. Ethnopharmacol. August 1991.
Anti-inflammatory, Pain-Relieving & Muscle-Relaxant Actions:
Jorge, R. M., et al. “Evaluation of antinociceptive, anti-inflammatory and antiulcerogenic activities of Maytenus ilicifolia.” J. Ethnopharmacol. 2004 Sep; 94(1): 93-100.
Hnatyszyn, O., et al. “Argentinian plant extracts with relaxant effect on the smooth muscle of the corpus cavernosum of guinea pig.” Phytomedicine. 2003 Nov; 10(8): 669-74.
Antioxidant Actions:
Vellosa, J. C., et al. "Antioxidant activity of Maytenus ilicifolia root bark." Fitoterapia. 2006 Apr; 77(3): 243-4.
Soares, L. A., et al. "Development and validation of a LC-method for determination of catechin and epicatechin in aqueous extractives from leaves of Maytenus ilicifolia." J. Pharm. Biomed. Anal. 2004 Nov; 36(4): 787-90.
Corsino, J., et al. "Antioxidant flavan-3-ols and flavonol glycosides from Maytenus aquifolium." Phytother. Res. 2003 Sep; 17(8) :913-6.
Vasorelaxant Actions:
Rattmann, Y. D., et al. "Nitric oxide-dependent vasorelaxation induced by extractive solutions and fractions of Maytenus ilicifolia Mart ex Reissek (Celastraceae) leaves." J. Ethnopharmacol. 2006 Apr; 104(3): 328-35.
Antimicrobial Actions:
Melo, S. F., et al. “Effect of the Cymbopogon citratus, Maytenus ilicifolia and Baccharis genistelloides extracts against the stannous chloride oxidative damage in Escherichia coli.” Mutat. Res. 2001 Sep; 496(1-2): 33-8.
de Lima, O. G., et al. “Antimicrobial substances from higher plants. XXXVI. On the presence of maytenin and pristimerine in the cortical part of the roots of Maytenus ilicifolia from the south of Brazil." Rev. Inst. Antibiot. 1971 Jun.
de Lima, O. G., et al. “Substabcias antimicrobiano de plantas superiores. Comunicacao XXXI. Maitenina, novo antimicrobiano con acao antineoplastica, isolade de celastracea de pernambuco.” Revista do Instituto de Antibioticos 1969; (9): 17–25.
Hormonal & Antifertility Actions:
Montanari, T., et al. “Effect of Maytenus ilicifolia Mart. on pregnant mice." Contraception. 2002 Feb; 65(2): 171–75.
Montanari, T., et al. “Effect of Maytenus ilicifolia Mart. Ex. Reiss on spermatogenesis." Contraception. 1998; 57(5): 335–39.
Bingel, A. S., et al. “Antifertility screening of selected plants in female rats.” Lloydia. 1976: 39(6): 475C.
Constitutents Identified:
Tiberti, L. A., et al. "Identification of flavonols in leaves of Maytenus ilicifolia and M. aquifolium (Celastraceae) by LC/UV/MS analysis." J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 2006 Sep 29;
Cipriani, T. R., et al. "An arabinogalactan isolated from the medicinal plant Maytenus ilicifolia." J. Nat. Prod. 2004; 67(4): 703-6.
Leite. J. P., et al. "Isolation and HPLC quantitative analysis of flavonoid glycosides from Brazilian beverages (Maytenus ilicifolia and M. aquifolium)." J. Agric. Food Chem. 2001; 49(8): 3796-801.
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* The statements contained herein have not been evaluated
by the Food and Drug Administration.
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not intended to treat, cure, mitigate or prevent any disease.
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Updated 1-17-2007
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