Bellaco-caspi Concentrated Extract - Himatanthus sucuuba - Bellaco capsi Extract - Himatanthus sucuuba - Bellaco-caspi Extract - Himatanthus lancifolius - Plumeria floribunda - Plumeria sucuuba - Plumeria lancifolia Bellaco-Caspi Extract

Himatanthus sucuuba

This product is no longer sold by Raintree Nutrition, Inc. See the main product page for more information why. Try doing a google search for products available from other suppliers or see the rainforest products page to find other companies selling rainforest herbal supplements or rainforest plants if you want to make this rainforest formula yourself.

A review of some of the chemicals found in bellaco caspi might explain some of the many traditional uses of this tropical rainforest tree. An antitumor iridoid compound and two depside chemicals have been isolated from bellaco caspi bark.* In addition, two iridoid chemicals called plumericin and isoplumericin have been found in the tree bark and the latex. These two chemicals have been reported with cytotoxic, anticancerous, antifungal and antibacterial actions in laboratory research.*

To learn more about this wonderful rainforest plant, go to the Tropical Plant Database file on Bellaco-Caspi. To see photographs of bellaco-caspi, click here. More information on bellaco caspi can also be found in the new Anti-Cancerous Guide and the new Antimicrobial Guide.

Traditional Uses:* as a wound healer and broad spectrum antimicrobial (bacteria, fungi, candida); for tumors and cancer; for lymphatic cleansing, inflammation, and infections; for endometriosis, uterine fibroid tumors, menstrual irregularities and pain, ovarian cysts and ovarian inflammation; as an anti-inflammatory and analgesic for arthritis, back pain, and muscle injury

Suggested Use: Take 60 drops (2 ml) of a concentrated 1:4 tincture 2 - 3 times daily or as needed. Can also be used topically on the skin as desired. To learn how to make your own extract, please refer to the instrutions on preparing tinctures at Methods for Preparing Herbal Remedies Page.

Contraindications: None reported.

Drug Interactions: None reported.





Third-Party Published Research*

All available third-party research on bellaco-caspi can be found at PubMed. A partial listing of the published research on bellaco-caspi is shown below:

Anti-tumor & Cytotoxic Actions:
In 2001, researchers in the United States reported that the bark of bellaco caspi was significantly cytotoxic in vitro to 5 different human cancer cell lines (breast, colon, prostate, lung, & lymphoma). They related this anticancerous action to the iridoids and triterpenoids chemicals discovered in the tree bark. It also passed a brine shrimp assay (which predicts antitumor activity) in 2003 and was shown to be active in vitro against malignant ascites at less than 20 mcg per ml.
Guignard, E., et al. "Screening of plants found in Amazonas state for lethality towards brine shrimp." Acta Amazonica. 2003; 33(1): 93-104.
Bolzani, V., et al. "Search for antifungal and anticancer compounds from native plant species of cerrado and Atlantic Forest." An. Acad. Bras. Cienc. 1999; 71(2): 181-7.
Persinos-Perdue, G., et al. " South American plants. III. Isolation of fulvoplumierin from Himatanthus sucuuba (Apocynaceae). J. Pharm. Sci. 1978; 67: 1322.
Kardono, L., et al. "Cytotoxic constituents of the bark of Plumeria rubra collected in Indonesia." J. Nat. Prod. 1990 Nov-Dec; 53(6):1447-55.
Wood, C. A., et al. "A bioactive spirolactone iridoid and triterpenoids from Himatanthus sucuuba." Chem. Pharm. Bull. 2001; 49(11): 1477-1478.
De Silva, J. R., et al. "Triterpenic esters from Himatanthus sucuuba (Spruce) Woodson." Quimica Nova 1998; 21(6): 702-704.
Abdel-Kader, M., et al. "Bioactive iridoids and a new lignan from Allamanda cathartica and Himatanthus fallax from the Suriname rainforest." J. Nat. Prod. 1997; 60(12): 1294-7.
Hamburger, M., et al. "Traditional medicinal plants of Thailand. XVII. Biologically active constituents of Plumeria rubra." J. Ethnopharmacol. 1991 Jul; 33(3): 289-92.

MAO-Inhibition Actions:
Endo, Y. et al. "Confluentic acid and 2'-o-methylperlatolic acid, Monoamine Oxidase B inhibitors in a Brazilian plant, Himatanthus sucuuba." Chem. Pharm. Bull. 1994; 42(6): 1198-1201.

Anti-ulcerous Actions:
Baggio, C., et al. "Gastroprotective mechanisms of indole alkaloids from Himatanthus lancifolius." Planta Med. 2005; 71(8): 733-8.

Anti-inflammatory, Pain-relieving and Wound Healing Actions:
de Lima, R., et al. "Database Survey of Anti-Inflammatory Plants in South America: A Review" Int J Mol Sci. 2011; 12(4): 26922749.
Lucetti, D., et al. "Anti-inflammatory effects and possible mechanism of action of lupeol acetate isolated from Himatanthus drasticus (Mart.) Plumel" J Inflamm (Lond) 2010; 7: 60.
Saleem, M. "Lupeol, A Novel Anti-inflammatory and Anti-cancer Dietary Triterpene" Cancer Lett. 2009 November 28; 285(2): 109115.
Villegas, L., et al. "Evaluation of the wound-healing activity of selected traditional medicinal plants from Peru." J. Ethnopharmacol. 1997; 55: 193-200.
De Miranda, A. L., et al. "Anti-inflammatory and analgesic activities of the latex containing triterpenes from Himatanthus sucuuba." Planta Med. 2000; 66(3): 284-286.

Anti-spasmodic Actions:
Rattmann, Y. et al. "Effects of alkaloids of Himatanthus lancifolius (Muell. Arg.) Woodson, Apocynaceae, on smooth muscle responsiveness." J. Ethnopharmacol. 2005 Sep; 100(3): 268-75.

Antimicrobial Actions:
In 1998, researchers in Brazil reported that the bark evidenced a greater antifungal effect than the control drug that was used (nistatin) and related this action to the triterpenic esters found in the bark. Research published in Brazil in 2006 and 2004 also reported in vitro antimicrobial effects of the bark against, Candida, E. coli, Staphylococcus, Bacillus, Mycobacterium phlei, and other Gram-positive and Gram-negative pathogenic bacteria. The latex was also documented with in vitro actions against Bacillus and Pseudomonas.
Kuigoua, G., et al. "Minor Secondary Metabolic Products from the Stem Bark of Plumeria rubra Linn. Displaying Antimicrobial Activities. Planta Med. 2009 Nov 20.
Moreira, D., et al. "Actividades antimicrobiologicas dos stratos e fracoes obtido atraves de solventes organicos da casca da Himatanthus sucuuba do vale do Acre." Anais Do XV Seminario De Iniciacao Cientifica PIBIQ-CNPQ, 2006: Universidade Federal Do Acre, Rio Branco-Acre, Brazil.
Souza, W., et al. "Antimicrobial activity of alkaloidal fraction from barks of Himatanthus lancifolius." Fitoterapia. 2004 Dec; 75(7-8): 750-3.
Little, J., et al. "Plumericin; an antimicrobial agent from Plumeria multiflora." Arch. Biochem. 1951; 30(2): 445-52.
Persinos-Perdue, G., et al. " South American plants. III. Isolation of fulvoplumierin from Himatanthus sucuuba (Apocynaceae). J. Pharm. Sci. 1978; 67: 1322.
Wood, C. A., et al. "A bioactive spirolactone iridoid and triterpenoids from Himatanthus sucuuba." Chem. Pharm. Bull. 2001; 49(11): 1477-1478.
De Silva, J. R., et al. "Triterpenic esters from Himatanthus sucuuba (Spruce) Woodson." Quimica Nova 1998; 21(6): 702-704.
Abdel-Kader, M., et al. "Bioactive iridoids and a new lignan from Allamanda cathartica and Himatanthus fallax from the Suriname rainforest." J. Nat. Prod. 1997; 60(12): 1294-7.
Hamburger, M., et al. "Traditional medicinal plants of Thailand. XVII. Biologically active constituents of Plumeria rubra." J. Ethnopharmacol. 1991 Jul; 33(3): 289-92.
Kardono, L., et al. "Cytotoxic constituents of the bark of Plumeria rubra collected in Indonesia." J. Nat. Prod. 1990 Nov-Dec; 53(6):1447-55.
Jovel, E., et al. "An ethnobotanical study of the traditional medicine of the Mestizo people of Suni Mirano, Loreto, Peru." J. Ethnopharmacol. 1996; (53): 149-156.
Bolzani, V., et al. "Search for antifungal and anticancer compounds from native plant species of cerrado and Atlantic Forest." An. Acad. Bras. Cienc. 1999; 71(2): 181-7.

Antileishmanial Actions:
Soares, D., et al. "Leishmanicidal activity of Himatanthus sucuuba latex against Leishmania amazonensis." Parasitol Int. 2010 Jun;59(2):173-7.
Castillo, D., et al. "Spirolactone iridoids might be responsible for the antileishmanial activity of a Peruvian traditional remedy made with Himatanthus sucuuba (Apocynaceae)." J. Ethnopharmacol. 2007 Jun 13; 112(2): 410-4.

Toxicity Studies:
De Oliveira Guerra, M., et al. "Screening for reproductive toxicity in rats for a decoction of Himathanthus sucuuba stem bark." J. Ethnopharmacol. 1991; 34(2/3): 195-199.


* The statements contained herein have not been evaluated
by the Food and Drug Administration. This product is
not intended to treat, cure, mitigate or prevent any disease.
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Last updated 12-31-2012