Amazon Menstrual Support
Amazon
MENSTRUAL SUPPORT
*

120 capsules (650 mg each)

This product is no longer sold by Raintree Nutrition, Inc. See the main product page for more information why. Try doing a google search or see the rainforest products page to find other companies selling rainforest herbal supplements or rainforest plants if you want to make this rainforest formula yourself.

A synergistic formula of 7 botanicals traditionally used in South America for menstrual pain, cramps and excessive bleeding.* For more information on the individual ingredients in Amazon Menstrual Support, follow the links provided below to the plant database files in the Tropical Plant Database.

Ingredients: A herbal blend of abuta, cumaseba, tayuya, bellaco caspi, iporuru, erva tostão, culen, chuchuhuasi, cramp bark, and ubos. To prepare this natural remedy yourself: use three parts abuta, two parts tayuya and iporuru, and one part each of the remaining plants in the list. To make a small amount... "1 part" could be one tablespoon (you'd have 14 tablespoons of the blended herbal formula). For larger amounts, use "1 part" as one ounce or one cup or one pound. Combine all the herbs together well. The herbal mixture can then be stuffed into capsules or brewed into tea, stirred into juice or other liquid, or taken however you'd like.

Suggested Use: Take 1.5 to 2 grams twice daily or as needed. (1 gram is approximately 1/2 teaspoon by volume)

Contraindications: Not to be used during pregnancy or while breast-feeding.

Drug Interactions: May potentiate hypotensive, cardiac depressant and anticoagulant medications.

Other Practitioner Observations:
  • Several plants in this formula have been documented to reduce blood pressure in animal studies. Individuals with low blood pressure should be monitored for this possible effect.
  • Erva tostão may have a cardiac depressant activity (based on animal studies). Those with a history of heart failure or those on cardiac depressant medications should be monitored for this possible effect.
  • Some women notice that this formula significantly reduces menstrual flow, which is normal.




Third-Party Published Research*

This rainforest formula has not been the subject of any clinical research. A partial listing of third-party published research on each herbal ingredient in the formula is shown below. Please refer to the plant database files by clicking on the plant names below to see all available documentation and research on each plant ingredient.

Abuta (Cissampelos pareira)
Abuta is commonly referred to as the "midwives' herb" throughout South America because of its long history of traditional use for all types of women's ailments. It is used in tropical countries to prevent a threatened miscarriage and to stop uterine hemorrhages after childbirth. Researchers report that abuta demonstrated anti-inflammatory, smooth muscle relaxant, antispasmodic, antitumor, and uterine relaxant actions in various laboratory animals.
Ganguly, M., et al. "Antifertility activity of the methanolic leaf extract of Cissampelos pareira in female albino mice." J. Ethnopharmacol. 2007 May; 111(3): 688-91.
Bullough, C., et al. “Herbal medicines used by traditional birth attendants in Malawi.” Trop. Geograph. Med. 1982; 34: 81-85.
Tiwari, K. C., et al. “Folklore information from Assam for family planning and birth control.” Int. J. Crude Drug Res. 1982 Nov; 20(3):133-7.
Feng, P. C., et al. “Pharmacological screening of some West Indian medicinal plants.” J. Pharm. Pharmacol. 1962; 14: 556–61.
Moreno, M. S. F., et al. “Action of several popular medicaments on the isolated uterus.“ C. R. Seances Soc. Biol. Ses. Fil. 1922; 87:563-564.
Chen, J., et al. "The relaxation mechanisms of tetrandrine on the rabbit corpus cavernosum tissue in vitro." Nat. Prod. Res. 2009; 23(2): 112-21.
Yuan, J., et al. "Effects of extracts and active components of Rhizoma Coptidis on contraction of circular smooth muscle isolated from guinea pig gastric antrum." Zhong Xi Yi Jie He Xue Bao. 2009; 7(9): 831-5.
Jeong, H., et al. "Berberine suppresses proinflammatory responses through AMPK activation in macrophages." Am. J. Physiol. Endocrinol. Metab. 2009 Apr; 296(4): E955-64.
Zhang, D., et al. "Tetrandrine ameliorates dextran-sulfate-sodium-induced colitis in mice through inhibition of nuclear factor -kappaB activation." Int. J. Colorectal Dis. 2009; 24(1):5-12.
Choi, B., et al. "The inhibition of inflammatory molecule expression on 3T3-L1 adipocytes by berberine is not mediated by leptin signaling." Nutr. Res. Pract. 2009 Summer; 3(2): 84-8.
Amresh, G., et al. "Antinociceptive and antiarthritic activity of Cissampelos pareira roots." J. Ethnopharmacol. 2007 May; 111(3): 531-6.
Wu, S. J.," Tetrandrine inhibits proinflammatory cytokines, iNOS and COX-2 expression in human monocytic cells." Biol. Pharm. Bull. 2007 Jan; 30(1): 59-62.
Choi, B. H., et al. "Berberine reduces the expression of adipogenic enzymes and inflammatory molecules of 3T3-L1 adipocyte." Exp. Mol. Med. 2006 Dec; 38(6): 599-605.
Amresh, G., et al. "Evaluation of anti-inflammatory activity of Cissampelos pareira root in rats." J. Ethnopharmacol. 2007 Apr; 110(3): 526-31.
Adesina, S. K. “Studies on some plants used as anticonvulsants in Amerindian and African traditional medicine.” Fitoterapia.1982; 53: 147–62.

Cumaseba (Swartzia polyphylla)
Cumaseba is rich is flavonoids and isoflavones. It contains a significant amount of a phytoestrogen chemical called biochanin A which has been well studied and documented (over 150 studies published to date). This tree bark is used in Peru for pain, inflammation, and cramps.
Kole, L., et al. "Biochanin-A, an isoflavon, showed anti-proliferative and anti-inflammatory activities through the inhibition of iNOS expression, p38-MAPK and ATF-2 phosphorylation and blocking NF?B nuclear translocation." Eur J Pharmacol. 2011 Feb 25;653(1-3):8-15
Sithisarn, P., et al. "Differential antiviral and anti-inflammatory mechanisms of the flavonoids biochanin A and baicalein in H5N1 influenza A virus-infected cells." Antiviral Res. 2012 Oct 23.
Du Bois, J. L., et al. “Dihydrolicoisoflavone, a new isoflavanone from Swartzia polyphylla.” J. Nat. Prod. 1995: 58(4): 629-632.
Du Bois, J. L., et al. “Fereirinol, a new 3-hydroxyisoflavanone from Swartzia polyphylla.” J. Nat. Prod. 1996; 59(9): 902-903.
Rojas, R., et al. “Larvicidal, antimycobacterial and antifungal compounds from the bark of the Peruvian plant Swartzia polyphylla DC.” Chem. Pharm. Bull. 2006; 54(2): 278-279.

Tayuya (Cayaponia tayuya)
Tayuya contains novel cucurbitacins chemicals with documented antioxidant, anti-inflammatory and pain-relieving properties.
Escandell, J. M., et al. "Inhibition of delayed-type hypersensitivity by Cucurbitacin R through the curbing of lymphocyte proliferation and cytokine expression by means of nuclear factor AT translocation to the nucleus." J Pharmacol Exp Ther. 2010 Feb;332(2):352-63.
Aquila, S., et al. "Anti-inflammatory activity of flavonoids from Cayaponia tayuya roots." J Ethnopharmacol. 2009 Jan 21;121(2):333-7.
Escandell, J., et al. "Dihydrocucurbitacin B inhibits delayed type hypersensitivity reactions by suppressing lymphocyte proliferation." J Pharmacol Exp Ther. 2007 Sep;322(3):1261-8.
Siqueira, J., et al. "Anti-inflammatory effects of a triterpenoid isolated from Wilbrandia ebracteata Cogn." Life Sci. 2007 Mar 20;80(15):1382-7.
Escandell, J. M., et al. "Cucurbitacin R reduces the inflammation and bone damage associated with adjuvant arthritis in Lewis rats by suppression of TNF-{alpha} in T lymphocytes and macrophages." J. Pharmacol. Exp. Ther. 2006 Feb; 532(1-2): 145-54.
Escandell, J. M., et al. “Dihydrocucurbitacin B, isolated from Cayaponia tayuya, reduces damage in adjuvant-induced arthritis.” Eur. J. Pharmacol. 2006 Feb; 532(1-2): 145-54.
Recio, M. C., et al. “Anti-inflammatory activity of two cucurbitacins isolated from Cayaponia tayuya roots.” Planta Med. 2004; 70(5): 414-20.
Himeno, E., et al. “Structures of cayaponosides A, B, C and D, glucosides of new nor-cucurbitacins in the roots of Cayaponia tayuya.” Chem. Pharm. Bull. (Tokyo) 1992; 40(10): 2885–87.
Ruppelt, B. M., et al. “Pharmacological screening of plants recommended by folk medicine as anti-snake venom—I. Analgesic and anti-inflammatory activities.” Mem. Inst. Oswaldo Cruz 1991; 86 (Suppl. 2): 203–5.
Rios, J. L., et al. “A study of the anti-inflammatory activity of Cayaponia tayuya root.” Fitoterapia 1990; 61(3): 275–78.
Faria, M. R. and E. P. Schenkel. “Caracterizacao de cucurbitacinas em especies vegetais cohecidas popularmente como taiuiá.” Ciencia e Cultura (São Paulo) 1987; 39: 970–73.
Bauer, R., et al. “Cucurbitacins and flavone C-glycosides from Cayaponia tayuya.” Phytochemisty. 1984: 1587–91.

Bellaco Caspi (Himatanthus sucuuba)
Brazilian researchers confirmed in 2000 that bellaco capsi evidenced significant anti-inflammatory and pain-relieving actions in laboratory animals (which also confirmed earlier anti-inflammatory research in 1978). In 2005 researchers documented its antispasmodic action. In Peru, this tree bark is used for menstrual disorders, for pain, and as an emmenagogue.
Rattmann, Y. et al. "Effects of alkaloids of Himatanthus lancifolius (Muell. Arg.) Woodson, Apocynaceae, on smooth muscle responsiveness." J. Ethnopharmacol. 2005 Sep; 100(3): 268-75.
de Lima, R., et al. "Database Survey of Anti-Inflammatory Plants in South America: A Review" Int J Mol Sci. 2011; 12(4): 2692–2749.
Lucetti, D., et al. "Anti-inflammatory effects and possible mechanism of action of lupeol acetate isolated from Himatanthus drasticus (Mart.) Plumel" J Inflamm (Lond) 2010; 7: 60.
Saleem, M. "Lupeol, A Novel Anti-inflammatory and Anti-cancer Dietary Triterpene" Cancer Lett. 2009 November 28; 285(2): 109–115.
Villegas, L., et al. "Evaluation of the wound-healing activity of selected traditional medicinal plants from Peru." J. Ethnopharmacol. 1997; 55: 193-200.
De Miranda, A. L., et al. "Anti-inflammatory and analgesic activities of the latex containing triterpenes from Himatanthus sucuuba." Planta Med. 2000; 66(3): 284-286.

Iporuru (Alchornea castaneifolia)
Iporuru is a well known analgesic remedy in Peruvian herbal medicine systems. Preliminary research has confirmed analgesic and anti-inflammatory actions in vitro and in animals.
Okoye, F., et al. "Topical anti-inflammatory constituents of lipophilic leaf fractions of Alchornea floribunda and Alchornea cordifolia." Nat Prod Res. 2011 Dec;25(20):1941-9.
Lopes, F., et al. "Anti-inflammatory activity of Alchornea triplinervia ethyl acetate fraction: inhibition of Hv(2)Ov(2), NO and TNF-?." Pharm Biol. 2010 Dec;48(12):1320-7.
Kouakou-Siransy, G., et al. "Effects of Alchornea cordifolia on elastase and superoxide anion produced by human neutrophils." Pharm Biol. 2010 Feb;48(2):128-33. Okoye, F., et al. "Anti-inflammatory and membrane-stabilizing stigmastane steroids from Alchornea floribunda leaves." Planta Med. 2010 Feb;76(2):172-7.
Manga, H., et al. "Anti-inflammatory compounds from leaves and root bark of Alchornea cordifolia (Schumach. & Thonn.) Müll. Arg." J Ethnopharmacol. 2008 Jan 4;115(1):25-9.
Manga, H.M., et al. “In vivo anti-inflammatory activity of Alchornea cordifolia (Schumach. & Thonn.) Mull. Arg. (Euphorbiaceae).” J. Ethnopharmacol. 2004 Jun; 92(2-3): 209-14.
Osadebe, P. O., et al. “Anti-inflammatory effects of crude methanolic extract and fractions of Alchornea cordifolia leaves.” J. Ethnopharmacol. 2003 Nov; 89(1):19-24.
Tona, L., et al. “Antiamoebic and spasmolytic activities of extracts from some antidiarrhoeal traditional preparations used in Kinshasa, Congo.” Phytomedicine. 2000 Mar; 7(1): 31-8.
Dunstan, C. A., et al. “Evaluation of some Samoan and Peruvian medicinal plants by prostaglandin biosynthesis and rat ear oedema assays.” J. Ethnopharmacol. 1997; 57: 35–56.
Ogungbamila, F. O., et al. “Smooth muscle–relaxing flavonoids from Alchornea cordifolia.” Acta Pharm. Nord. 1990; 2(6): 421–22.
Persinos-Perdue, G., et al. “Evaluation of Peruvian folk medicine by the natural products research laboratories.” Abstra. Joint Meeting American Society of Pharmacognosy and Society for Economic Botany, Boston, 1981; (5) 13

Erva Tostão (Boerhaavia diffusa)
Erva tostão is considered an emmenagogue in herbal medicine systems around the world and employed for a variety of menstrual disorders. Laboratory studies indicate it has prin-relieving, anti-inflammatory, antihemorrhagic, antispasmodic, and diuretic actions. In two studies with monkeys, erva tostão was reported to reduce bleeding and uterine hemorrhaging commonly associated with wearing contraceptive IUDs. These researchers also reported that erva tostão may be beneficial for menorrhagia (excessive menstruation) as it reduced the duration of menstrual flow in their animal test subjects.
Barthwal, M., et al. “Management of IUD-associated menorrhagia in female rhesus monkeys (Macaca mulatta)." Adv. Contracept. 1991; 7(1): 67–76.
Barthwal, M., et al. “Histologic studies on endometrium of menstruating monkeys wearing IUDS: comparative evaluation of drugs.” Adv. Contracept. 1990; 6(2): 113–24.
Irié-N'guessan, G., et al. "Tracheal relaxation of five Ivorian anti-asthmatic plants: role of epithelium and K^(+) channels in the effect of the aqueous-alcoholic extract of Dichrostachys cinerea root bark." J Ethnopharmacol. 2011 Nov 18;138(2):432-8.
Kaur, M., et al. "Anti-Convulsant Activity of Boerhaavia diffusa: Plausible Role of Calcium Channel Antagonism." Evid Based Complement Alternat Med. 2011;2011:310420.
Borrelli, F., et al. "Spasmolytic effects of nonprenylated rotenoid constituents of Boerhaavia diffusa roots." J. Nat. Prod. 2006; 69(6): 903-6.
Borrelli, F., et al. “Isolation of new rotenoids from Boerhaavia diffusa and evaluation of their effect on intestinal motility.” Planta Med. 2005; 71(10): 928-32.
Hiruma-Lima, C. A., et al. “The juice of fresh leaves of Boerhaavia diffusa L. (Nyctaginaceae) markedly reduces pain in mice." J. Ethnopharmacol. 2000; 71(1–2): 267–74.
Akah, P., et al. “Nigerian plants with anti-convulsant property.” Fitoterapia 1993; 64(1): 42–44.
Adesina, S. “Anticonvulsant properties of the roots of Boerhaavia diffusa.” Q. J. Crude Drug Res. 1979; 17: 84–86.
Dhar, M., et al. “Screening of Indian plants for biological activity: Part I.” Indian J. Exp. Biol. 1968; 6: 232–47.

Culen (Psoralea glandulosa)
Culen is used in Bolivia as an emmenagogue to balance menstrual cycles and for various female complaints.
Lim, S., et al. "Estrogenic activities of Psoralea corylifolia L. seed extracts and main constituents." Phytomedicine. 2011 Mar 15;18(5):425-30.
Yang, Z., et al. "The osteoprotective effect of psoralen in ovariectomy-induced osteoporotic rats via stimulating the osteoblastic differentiation from bone mesenchymal stem cells." Menopause. 2012 Oct;19(10):1156-64.
Don, M., et al. "Neobavaisoflavone stimulates osteogenesis via p38-mediated up-regulation of transcription factors and osteoid genes expression in MC3T3-E1 cells." Phytomedicine. 2012 Apr 15;19(6):551-61.
Ming, L., et al. "[Effects of isopsoralen on bone marrow stromal stem cells differentiate and proliferate in vitro]." Zhongguo Zhong Yao Za Zhi. 2011 Aug;36(15):2124-8.
Ming, L., et al. "[Effect of isopsoralen on the proliferation and differentiate of osteoblasts in vitro]." Zhong Yao Cai. 2011 Mar;34(3):404-8.

Chuchuhausi (Maytenus macrocarpa, krukovii)
Chuchuhuasi has been traditionally used in Peru as a muscle relaxant, aphrodisiac, and analgesic; for adrenal support, as an immune stimulant, and for menstrual balance and regulation. Laboratory tests indicates it has analgesic and anti-inflammatory actions.
Sosa, S., et al. "Anti-inflammatory activity of Maytenus senegalensis root extracts and of maytenoic acid." Phytomedicine. 2007; 14(2-3): 109-14.
Honda, T., et al. “Partial synthesis of krukovines A and B, triterpene ketones isolated from the Brazilian medicinal plant Maytenus krukovii.” J. Nat. Prod. 1997; 60(11): 1174-77.
Morita, H., et al. “Triterpenes from Brazilian medicinal plant “chuchuhuasi” (Maytenus krukovii).” J. Nat. Prod. 1996; 59(11): 1072-75.
Sekar K. V., et al. “Mayteine and 6-benzoyl-6-deacetyl-mayteine from Maytenus krukovii.” Planta Med. 1995; 61: 390.
Bradshaw, D., et al. “Therapeutic potential of protein kinase C inhibitors.” Agents and Actions 1993; 38: 135-47.
Itokawa, H., et al. “Isolation, structural elucidation and conformational analysis of sesquiterpene pyridine alkaloids from Maytenus ebenifolia Reiss. X-ray molecular structure of ebenifoline W-1.” J. Chem. Soc. Perkin. Trans. I 1993; 11: 1247-54.
Itokawa, H., et al. “Oligo-nicotinated sesquiterpene polyesters from Maytenus ilicifolia.” J. Nat. Prod. 1993; 56: 1479-85.
Gonzalez, J. G., et al. “Chuchuhuasha—a drug used in folk medicine in the Amazonian and Andean areas. A chemical study of Maytenus laevis.” J. Ethnopharm. 1982; 5: 73–7
Moya, S., et al. “Phytochemical and pharmacological studies on the antiarthritics of plant origin.” Rev. Colomb. Cienc. Quim. Farm. 1977; 3(2): 5.

Cramp Bark (Viburnum opulus)
Cramp bark is a long used and popular medicinal herb in North America which is widely used for men-strual cramps and pain. Cramp bark's sedating and relaxing actions are thought to be specific to the reproductive system. It also has an astringent actions; useful in cases of excessive menstrual bleeding.
Cesoniene, L., et al. "Determination of the total phenolic and anthocyanin contents and antimicrobial activity of Viburnum opulus fruit juice." Plant Foods Hum Nutr. 2012 Sep;67(3):256-61.
Erdogan-Orhan, I., et al. "Anti-acetylcholinesterase and antioxidant assets of the major components (salicin, amentoflavone, and chlorogenic acid) and the extracts of Viburnum opulus and Viburnum lantana and their total phenol and flavonoid contents." J Med Food. 2011 Apr;14(4):434-40.
Zayachkivska, O., et al. "Influence of Viburnum opulus proanthocyanidins on stress-induced gastrointestinal mucosal damage." J Physiol Pharmacol. 2006 Nov;57 Suppl 5:155-67.
Nicholson, J. A., et al. “Viopudial, a hypotensive and smooth muscle antispasmodic from Viburnum opulus.” Proc. Soc. Exp. Biol. Med. 1972 Jun; 140(2): 457-61.
Smirnova, A. S., et al. “[Comparative study of the astringent effect of liquid extracts from Viburnum opulus L].” Farmatsiia. 1968 Jul-Aug; 17(4): 42-5.

Ubos (Spondias mombin)
Ubos is traditonally used as a menstrual regulator and for menstrual pain, cramps and irregularity, vaginal infections and yeast infections.Published research indicated ubos has uterine stimulant actions, muscle relaxant and uterine antispamodic actions.
Akubue, P., et al. "Preliminary pharmacological study of some Nigerian medicinal plants." J. Ethnopharmacol. 1983; 8(1): 53-63.
Uchendu, C., et al. "Spasmogenic activity of butanolic leaf extract of Spondias mombin in isolated uterine muscle of the rat: role of calcium. J. Nat. Remedies 2005; 5(1): 7-14.
Uchendu, C., et al. "Antifertility activity of aqueous ethanolic leaf extract of Spondias mombin (Anacardiaceae) in rats." Afr Health Sci. 2008 Sep;8(3):163-7.
Offiah, V., et al. "Abortifacient activity of an aqueous extract of Spondias mombin leaves." J. Ethnopharmacol 1989; 26(3): 317-320.
Barros, G., et al. "Pharmacological screening of some Brazilian plants." J. Pharm. Pharmacol. 1970; 22: 116.
Akubue, P., et al. "Preliminary pharmacological study of some Nigerian medicinal plants." J. Ethnopharmacol. 1983; 8(1): 53-63.



*The statements contained herein have not been evaluated
by the Food and Drug Administration. The information contained herein is intended and provided for education, research, entertainment and information purposes only. This information is not intended to be used to diagnose, prescribe or replace proper medical care. The plants and/or formulas described herein are not intended to treat, cure, diagnose, mitigate or prevent any disease and no medical claims are made.
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