A non-alcohol botanical extract formula which combines the plants traditionally used in South America and the Amazon for coughs and sore throats.* A new and proprietary extraction method is used to concentrate and preserve the active ingredients found in these rainforest plants. Concentration and extraction methods provide the equivalent of 500 milligrams of plants per milliliter of extract. This product is backed by Raintree's unconditional guarantee.

For more information on the individual ingredients in Throat-Ez, follow the links provided below to the plant database files in the Tropical Plant Database.

Ingredients: A proprietary blend of embauba, guaco, culen, amor seco, bellaco caspi, ayapana, matico, and canchalagua extracted in distilled water, vegetable glycerine, and honey. These plants are non-irradiated and non-fumigated. They have been sustainably wild-harvested in South America where they have grown naturally without any pesticides, or fertilizers.
Suggested Use: Take 60 drops (2 ml) every 3 - 4 hours as needed
Contraindications: Not to be used during pregnancy or while breast-feeding.
Drug Interactions: Guaco contains natural coumarin. As such, it is possible that this product may enhance or increase the effect of coumadin (blood thinning) drugs.

A 2 ounce bottle is $21.95 each
Or buy 3 bottles for $20.95 each
Or buy 6 bottles for $18.95 each

This proprietary Raintree product has not been the subject of any clinical research. A partial listing of the available published research and documented traditional uses on each herbal ingredient in the formula is shown below. Please refer to the plant database files by clicking on the plant names below to see all available documentation and research.

Embauba (Cecropia peltata)
In Brazilian herbal medicine systems embauba is traditionally used for all types of respiratory complaints (such as asthma, bronchitis, coughs, whooping cough, and pneumonia).*
Rojas, J. J., et al. “Screening for antimicrobial activity of ten medicinal plants used in Colombian folkloric medicine: A possible alternative in the treatment of non-nosocomial infections.” BMC Complement. Altern. Med. 2006; 6(1): 2.
Zavala, M. A., et al. “Antimicrobial screening of some medicinal plants.” Phytother. Res. 1997; 11(5): 368–71.

Guaco (Mikania guaco, glomerata)
In 1870, a Brazilian herbal drug called Opodeldo de Guaco was made from guaco that was considered a "Saint's remedy" to treat bronchitis, coughs and rheumatism. This "drug" is still a popular home remedy today throughout Brazil for the same purposes but locals prepare it themselves by boiling guaco leaves into a tasty spicy cough syrup.*
Soares de Moura, R., et al. “Bronchodilator activity of Mikania glomerata Sprengel on human bronchi and guinea-pig trachea.” J. Pharm. Pharmacol. 2002; 54(2): 249-56.
Fierro, I. M., et al. “Studies on the anti-allergic activity of Mikania glomerata.” J. Ethnopharmacol. 1999; 66(1): 19-24.
Leite, M. G. R., et al. “Bronchodilator activity of Mikania glomerata, Justicia pectoralis and Torresea cearensis." Simposio de Plantas Medicinais do Brazil. December 1992. Curitiba. Resumos. p. 21.
Yatsuda, R., et al. “Effects of Mikania genus plants on growth and cell adherence of Mutans streptococci.” J. Ethnopharmacol. 2005; 97(2): 183-9.

Culen (Psoralea glandulosa)
In Chile culen is traditionally used as a bronchodilator and in Brazil it is traditionally used for asthma.*
Backhouse, C., et al. “Active constituents isolated from Psoralea glandulosa L. with antiinflammatory and antipyretic activities.” J. Ethnopharmacol. 2001; 78(1): 27-31.
Erazo, S., et al. “Antimicrobial activity of Psoralea glandulosa L.” Int. J. Pharmacog. 1997; 35(5): 385-387.
Kaul, R. “Kinetics of the antistaphylococcal activity of bakuchiol in vitro.” Arzneim-Forsch. 1976; (26): 486-513.

Amor Seco (Desmodium adscendens)
In several South American and African countries amor seco is traditionally used for bronchial asthma.*
Addy, M. E., et al. “Effect of Desmodium adscendens fraction 3 on contractions of respiratory smooth muscle.” J. Ethnopharmacol. 1990; 29(3): 325–35.
Addy, M. E., et al. “Effect of Desmodium adscendens fraction F1 (DAFL) on tone and agonist-induced contractions of guinea pig airway smooth muscle.” Phytother. Res. 1989; 3(3): 85–90.
Addy, M. E., et al. “Several chromatographically distinct fractions of Desmodium adscendens inhibit smooth muscle contractions.” Int. J. Crude Drug Res. 1989; 27(2): 81–91.
Addy, M. E., et al. “Effect of Desmodium adscendens fractions on antigen- and arachidonic acid-induced contractions of guinea pig airways.” Can. J. Physiol. Pharmacol. 1987; 66(6): 820–25.
Addy, M. E., et al. “Dose-response effect of one subfraction of Desmodium adscendens aqueous extract on antigen- and arachidonic acid-induced contractions of guinea pig airways.” Phytother. Res. 1987; 1(4): 180–86.

Bellaco-Caspi (Himatanthus sucuuba, lancifolius)
In Peruvian herbal medicine systems bellaco-caspi is traditionally used to relieve pain, inflammation, and fever.*
Villegas, L., et al. "Evaluation of the wound-healing activity of selected traditional medicinal plants from Peru." J. Ethnopharmacol. 1997; 55: 193-200.
De Miranda, A. L., et al. "Anti-inflammatory and analgesic activities of the latex containing triterpenes from Himatanthus sucuuba." Planta Med. 2000; 66(3): 284-286.
Rattmann, Y. et al. "Effects of alkaloids of Himatanthus lancifolius (Muell. Arg.) Woodson, Apocynaceae, on smooth muscle responsiveness." J. Ethnopharmacol. 2005 Sep; 100(3): 268-75.
Souza, W., et al. "Antimicrobial activity of alkaloidal fraction from barks of Himatanthus lancifolius." Fitoterapia. 2004 Dec; 75(7-8): 750-3.

Ayapana (Ayapana triplinervis, Eupatorium ayapana)
In Brazilian herbal medicine, an infusion of ayapana leaves is mixed with honey and used for coughs and sore throats.*
Jelager, L., et al. “Antibacterial and antifungal activity of medicinal plants of Mauritius.” Pharmaceutical Biol. 1998; 36:153-161.
Gupta, M., et al. “Antimicrobial activity of Eupatorium ayapana.” Fitoterapia. 2002; 73 (2):168-170.
Verpoorter, R., et al. “Medicinal plants of Surinam. IV. Antimicrobial activity of some medicinal plants.” J. Ethnopharmacol. 1987; 21: 315-318.
Kokate, C. K., et al. “Pharmacological studies on the essential oil of Eupatorium triplinerve. I. Effects on the central nervous system and antimicrobial activity.” Flavour. 1971; 2 (3): 177-180.

Matico (Piper aduncum)
In South America, matico is traditionally used for various upper respiratory conditions such as bronchitis, pulmonary hemorrhages, pleurisy, pneumonia, colds and flu, and tonsilitis and sore throats.*
Kloucek, P., et al. “Antibacterial screening of some Peruvian medicinal plants used in Calleria district.” J. Ethnopharmacol. 2005 Jun; 99(2): 309-12.
Orjala, J., et al. “Aduncamide, a cytotoxic and antibacterial beta-phenylethylamine-derived amide from Piper aduncum.” Nat. Prod. Lett. 1993; 2(3): 231-236.
Lohezic, L. E., et al. “Antiviral and cytotoxic activities of some Indonesian plants.” Fitoterapia. 2002 Aug; 73(5): 400-5.

Canchalagua (Schkuhria pinnata)
In Argentina and Peru canchalagua is traditionally used for coughing and upper respiratory infections.*
Weimann, C., et al. "Spasmolytic effects of Baccharis conferta and some of its constituents." J. Pharm. Pharmacol. 2002; 54(1): 99-104.
Anesini, C., et al. "Screening of plants used in Argentine folk medicine for antimicrobial activity." J. Ethnopharmacol. 1993; 39(2): 119-128.
Perez, C., et al. "In vitro antibacterial activity of Argentine folk medicinal plants against Salmonella typhi." J. Ethnopharmacol. 1994; 44(1): 41-46.
Tanaguchi, M., "Screening of East African plants for antimicrobial activity. I." Chem. Pharm. Bul. 1978: 2910-2913.
De Marino, S., et al. "New sesquiterpene lactones from Laurus nobilis leaves as inhibitors of nitric oxide production." Planta Med. 2005; 71(8): 706-10.

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