Matico is a tropical, evergreen, shrubby tree that grows to the height of 6 to 7 m with lanceolate leaves that are 12 to 20 cm long. It is native to most all of tropical South America as well as Southern Mexico, the Caribbean, and much of tropical Latin America. To learn more about this wonderful rainforest plant, go to the Tropical Plant Database file on Matico.

Traditional Uses:* for digestive problems (vomiting, nausea, stomachaches, dyspepsia); as a carminative and stomachic to expel intestinal gas and aid digestion; as an antiseptic wound healer for cuts, scrapes, ulcers, boils, etc.; as a hemostat for internal bleeding (uterine, gastric, pulmonary); for colds, flu, coughs, bronchitis, pneumonia and other respiratory problems

Ingredients: 100% pure matico leaves (Piper aduncum) extracted in distilled water and vegetable glycerine. No chemical additives or preservatives are used. Concentration and extraction methods provide the equivalent of 500 mg matico leaves per milliliter of extract. This product is non-irradiated and non-fumigated. It is a wild harvested product—grown naturally in the Peruvian Amazon without any pesticides or fertilizers.

Suggested Use: Take 60 drops 2 - 3 times daily or as needed. Can also be applied topically to the skin if desired.

Contraindications: None known.

Drug Interactions: None known.

A 2 ounce bottle is $21.95 each
Or buy 3 bottles for $20.95 each
Or buy 6 bottles for $18.95 each

This Raintree product has not been the subject of any clinical research. All available third-party research on matico be found at PubMed. A partial listing of the third-party published research on matico is shown below:

Cytotoxic & Antitumor Actions:
Orjala, J., et al. “Two chromenes and a prenylated benzoic acid derivative from Piper aduncum.” Phytochemistry. 1993; 34(3): 813-818.
Orjala, J., et al. “Cytotoxic and antibacterial dihydrochalcones from Piper aduncum.” J. Nat. Prod. 1994; 57(1): 18-26
Orjala, J., et al. “Aduncamide, a cytotoxic and antibacterial beta-phenylethylamine-derived amide from Piper aduncum.” Nat. Prod. Lett. 1993; 2(3): 231-236.

Antibacterial Actions:
Orjala, J., et al. “New monoterpene-substituted dihydrochalcones from Piper aduncum.” Helv. Chim. Acta 1993; 76(4): 1481-1488.
Kloucek, P., et al. “Antibacterial screening of some Peruvian medicinal plants used in Calleria district.” J. Ethnopharmacol. 2005 Jun; 99(2): 309-12.
Lemos, T. L. G., et al. “Antimicrobial activity of essential oils of Brazilian plants.” Phytother. Res. 1990; 4(2): 82-84.
Lentz, D. L., et al. “Antimicrobial properties of Honduran medicinal plants.” J. Ethnopharmacol, 1998; 63(3): 253-263.
Trillini, B., et al. “Chemical composition and antimicrobial activity of essential oil of Piper angustifolium.” Planta Med. 1996; 62(4): 372-373.
Orjala, J., et al. “Cytotoxic and antibacterial dihydrochalcones from Piper aduncum.” J. Nat. Prod. 1994; 57(1): 18-26
Orjala, J., et al. “Three new prenylated benzoic acid derivatives and molluscicidal sesquiterpenoids from Piper aduncum leaves.” Planta Med. Suppl. 1992; 58(1) A714-.
Orjala, J., et al. “Five new prenylated p-hydroxybenzoic acid derivatives with antimicrobial and molluscicidal activity from Piper aduncum leaves.” Planta Med. 1993; 59(6): 546-551.
Orjala, J., et al. “Aduncamide, a cytotoxic and antibacterial beta-phenylethylamine-derived amide from Piper aduncum.” Nat. Prod. Lett. 1993; 2(3): 231-236.

Antifungal Actions:
Orjala, J., et al. “Two chromenes and a prenylated benzoic acid derivative from Piper aduncum.” Phytochemistry. 1993; 34(3): 813-818.
Lemos, T. L. G., et al. “Antimicrobial activity of essential oils of Brazilian plants.” Phytother. Res. 1990; 4(2): 82-84.
Lentz, D. L., et al. “Antimicrobial properties of Honduran medicinal plants.” J. Ethnopharmacol, 1998; 63(3): 253-263.
Trillini, B., et al. “Chemical composition and antimicrobial activity of essential oil of Piper angustifolium.” Planta Med. 1996; 62(4): 372-373.
Lago, J. H., et al. “Benzoic acid derivatives from Piper species and their fungitoxic activity against Cladosporium cladosporioides and C. sphaerospermum.” J. Nat. Prod. 2004; 67(11):1783-8.
Navickiene, H., et al. “Composition and antifungal activity of essential oils from Piper aduncum, Piper arboreum and Piper tuberculatum.” Quim. Nova. 2006; 20( 3): 467-470.

Anti-Candida & Anti-yeast Actions
Lemos, T. L. G., et al. “Antimicrobial activity of essential oils of Brazilian plants.” Phytother. Res. 1990; 4(2): 82-84.
Lentz, D. L., et al. “Antimicrobial properties of Honduran medicinal plants.” J. Ethnopharmacol, 1998; 63(3): 253-263.
Trillini, B., et al. “Chemical composition and antimicrobial activity of essential oil of Piper angustifolium.” Planta Med. 1996; 62(4): 372-373.

Antiviral Actions:
Lohezic, L. E., et al. “Antiviral and cytotoxic activities of some Indonesian plants.” Fitoterapia. 2002 Aug; 73(5): 400-5.

Anti-Leishmanial Actions:
Torres-Santos, E. C., et al. Selective effect of 2',6'-dihydroxy-4'-methoxychalcone isolated from Piper aduncum on Leishmania amazonensis.” Antimicrob. Agents Chemother. 1999; 43(5): 1234-1241.
Torres-Santos, E. C., et al. Improvement of in vitro and in vivo antileishmanial activities of 2', 6'-dihydroxy-4'-methoxychalcone by entrapment in poly(D,L-lactide) nanoparticles.” Antimicrob. Agents Chemother. 1999; 43(7): 1776-8.

Anti-schistosomiasis & Molluscicidal Actions:
Orjala, J., et al. “Two chromenes and a prenylated benzoic acid derivative from Piper aduncum.” Phytochemistry. 1993; 34(3): 813-818.
Orjala, J., et al. “Three new prenylated benzoic acid derivatives and molluscicidal sesquiterpenoids from Piper aduncum leaves.” Planta Med. Suppl. 1992; 58(1) A714-.
Orjala, J., et al. “Five new prenylated p-hydroxybenzoic acid derivatives with antimicrobial and molluscicidal activity from Piper aduncum leaves.” Planta Med. 1993; 59(6): 546-551.

Insecticidal Actions:
Hidayatulfathi, O., et al. “Adulticidal activity of some Malaysian plant extracts against Aedes aegypti Linnaeus.” J. Trop. Biomed. 2004 Dec; 21(2): 61-7.
Estrela, J., et al. "Toxicity of essential oils of Piper aduncum and Piper hsipidinervum against Sitophilus zeamais." Pesq. Agroped. Bras. 2006; 41(2): 217-222.

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Matico Tech Report -- A Technical Plant Data Report is available for matico.