Some of the active ingredients documented, researched, and verified in Guacatonga are a group of clerodane diterpenes. These phytochemicals are being researched and patented for their active biological properties and potential uses.*
Raintree's guacatonga has been sustainably harvested in the Amazon Rainforest and the capsules are 100% pure natural herb without any binders, fillers or additives. For more complete information on this unique rainforest plant, please see plant database file on guacatonga. A free Technical Data Report (normally sells for $20.00!) is available for guacatonga.
Raintree's guacatonga capsules are sold in bottles of 100 capsules with 600 milligrams per capsule of pure guacatonga ground leaf and stem, rich in active and beneficial phytochemicals which occur naturally in this plant. We use no binders or fillers so the capsules are 100% pure finely milled guacatonga powder. Raintree's guacatonga has been sustainably wild harvested (without pesticides or fertilizers) in the Brazilian Amazon rainforest and is unconditionally guaranteed.
Traditional Uses:* for cancer (sarcoma, carcinoma, and adenocarcinoma); for stomach disorders (ulcers, acid reflux, indigestion, dyspepsia, stomachache); as an antivenin for snake, spider and bee bites and stings; as a topical analgesic (pain-reliever) and anti-inflammatory for skin diseases, rashes and wounds; as a blood purifier and for general detoxification
Ingredients: 100% pure guacatonga (Casearia sylvestris) leaf & stem. No binders, fillers or additives are used. This plant is non-irradiated and non-fumigated.
Suggested Use: Take 3 capsules 2-3 times daily or as directed by a healthcare professional.
Contraindications: Not to be used during pregnancy or while breast-feeding.
Drug Interactions: None reported.
Other Observations: None reported.
A 100 capsule bottle is $18.95 each
Or buy 3 bottles for $17.95 each
Or buy 6 bottles for $15.95 each
Third-Party Published Research*
This Raintree product has not been the subject of any clinical research.
All available third-party research on guacatonga can be found at PubMed/Medline.
A partial listing of the published research on guacatonga is shown below:
Cytotoxic & Anticancerous Actions: Balunas, M. J., et al. "Relationships between inhibitory activity against a cancer cell line panel, profiles of plants collected, and compound classes isolated in an anticancer drug discovery project." Chem. Biodivers. 2006; 3(8): 897-915.
Shen, Y. C., et al. "Cytotoxic clerodane diterpenoids from Casearia membranacea." J. Nat. Prod. 2005; 68(11): 1665-8.
Maistro, E. L., et al. “Evaluation of the genotoxic potential of the Casearia sylvestris extract on HTC and V79 cells by the comet assay.” Toxicol. In Vitro. 2004 Jun; 18(3): 337-42.
Oberlies, N. H., et al. “Novel bioactive clerodane diterpenoids from the leaves and twigs of Casearia sylvestris.” J. Nat. Prod. 2002; 65(2): 95–99.
Sai Prakash, C. V., et al. “Structure and stereochemistry of new cytotoxic clerodane diterpenoids from the bark of Casearia lucida from the Madagascar rainforest.” J. Nat. Prod. 2002; 65(2): 100-7.
Beutler, J. A. “Novel cytotoxic diterpenes from Casearia arborea.” J. Nat. Prod. 2000; 63(5): 657-61.
Almeida, A. “Antitumor and anti-inflammatory effects of extract from Casearia sylvestris: comparative study with Piroxicam and Meloxicam.” Instituto de Ciencias Biomedicas, University of Sao Paulo (Dissertation, 4/02/99).
Itokawa, H., et al. “Antitumor substances from South American plants.” J. Pharmacobio. Dyn. 1992; 15(1): S-2-.
Morita, H., et al. “Structures and cytotoxic activity relationship of casearins, new clerodane diterpenes from Casearia sylvestris Sw.” Chem. Pharm. Bull. (Tokyo) 1991 Dec; 39(3): 693–97.
Itokawa, H., et al. “New antitumor principles, casearins A–F, for Casearia sylvestris Sw. (Flacourtiaceae).” Chem. Pharm. Bull. (Tokyo) 1990; 38(12): 3384–88.
Itokawa, H., et al. “Isolation of diterpenes as antitumor agents from plants.” Patent—Japan Kokai Tokyo Koho–01 1989; 149, 779: 6pp.
Itokawa, H., et al. “Antitumor principles from Casearia sylvestris Sw. (Flacourtiaceae), structure elucidation of
new clerodane diterpenes by 2-D NMR spectroscopy.” Chem. Pharm. Bull. (Tokyo) 1988 March; 36(4): 1585–88.
Antiulcer & Antacid Actions: Esteves, I., et al. “Gastric antiulcer and anti-inflammatory activities of the essential oil from Casearia sylvestris Sw.” J. Ethnopharmacol. 2005 Oct; 101(1-3): 191-6.
Sertie, J. A., et al. “Antiulcer activity of the crude extract from the leaves of Casearia slyvestris.” Pharmaceutical Biol. 2000; 38(2): 112–19.
Basile, A. C., et al. “Pharmacological assay of Casearia sylvestris. I: Preventive anti-ulcer activity and toxicity of the leaf crude extract.” J. Ethnopharmacol. 1990; 30(2): 185–97.
Neuroprotective Actions: da Silva, A. C., et al. "Inhibition of NTPDase, 5'-nucleotidase, Na+/K+-ATPase and acetylcholinesterase activities by subchronic treatment with Casearia sylvestris." Phytomedicine. 2006; 13(7): 509-14.
Antivenin Actions: Raslan, D.S., et al. “Anti-PLA2 action test of Casearia sylvestris Sw.” Boll. Chim. Farm. 2002 Nov-Dec; 141(6): 457-60.
Borges, M., et al. “Neutralization of proteases from Bothrops snake venoms by the aqueous extract from Casearia sylvestris (Flacourtiaceae).” Toxicon 2001; 39(12): 1863–69.
Borges, M., et al. “Effects of aqueous extract of Casearia sylvestris (Flacourtiaceae) on actions of snake and bee venoms and on activity of phospholipases A(2).” Comp. Biochem. Physiol. B. 2000 Sep 1; 127(1): 21–30.
Borges, M., et al. “Partial purification of Casearia sylvestris Sa. extract and its anti-PLA2 Action.” Comp. Biochem. Physiol. Ser. B. 2000; 127b(1): 21–30.
Ruppelt, B. M., et al. “Pharmacological screening of plants recommended by folk medicine as antisnake venom—I. Analgesic and anti-inflammatory activities.” Mem. Inst. Oswaldo Cruz 1991; 86: 203–05.
Anti-inflammatory & Pain-Relieving Actions: Silva, F.B., et al. “Natural medicaments in endodontics—a comparative study of the anti-inflammatory action.” Pesqui. Odontol. Bras. 2004 Apr-Jun; 18(2): 174-9.
Almeida, A. “Antitumor and anti-inflammatory effects of extract from Casearia sylvestris: comparative study with Piroxicam and Meloxicam.” Instituto de Ciencias Biomedicas, University of Sao Paulo (Dissertation, 4/02/99).
Antimicrobial, Antiparasitic, & Insecticidal Actions: de Mesquita, M. L.,et al. "In vitro antiplasmodial activity of Brazilian Cerrado plants used as traditional remedies." J. Ethnopharmacol. 2007 Mar; 110(1): 165-70.
Rodrigues, A. M., et al. "Larvicidal activity of some Cerrado plant extracts against Aedes aegypti." J. Am. Mosq. Control Assoc. 2006 Jun; 22(2): 314-7.
Mesquita, M.L., et al. “Antileishmanial and trypanocidal activity of Brazilian Cerrado plants.” Mem. Inst. Oswaldo Cruz. 2005 Nov; 100(7): 783-7.
Espindola, L. S., et al. “Trypanocidal activity of a new diterpene from Casearia sylvestris var. lingua.” Planta Med. 2004; 70(11): 1093-5.
de Almeida Alves, T. M. “Biological screening of Brazilian medicinal plants.” Mem. Inst. Oswaldo Cruz. 2000 May/Jun; 95(3): 367–73.
Chiappeta, A. D., et al. “Higher plants with biological activity—plants of Pernambuco. I.” Rev. Inst. Antibiot. 1983; 21(1/2): 43–50.
RELATED PRODUCTS:
Guacatonga can be found in these proprietary Raintree products:
Guacatonga Tech Report -- A FREE Technical Plant Data Report is available for guacatonga.
* The statements contained herein have not been evaluated by the Food and Drug Administration.
This product is not intended to treat, cure, mitigate or prevent any disease. Please refer to our Conditions of Use for this web site and product.
