Some of the active ingredients documented, researched, and verified in graviola are a group of Annonaceous acetogenins which are only found in the Annonaceae plant family. Graviola (Annona muricata) has 82 different acetogenin chemicals (in
10 distinct types). Mountain graviola (Annona montana) contains the main annonacin chemical that graviola does, and, it has 26 more acetogenin chemicals not found in graviola (in 6 distinct types)! Graviola Max combines both species of graviola (Annona muricata and Annona montana) to provide 12 different types of acetogenins—108 distinct powerful chemicals in all. Compare that to only 28 acetogenin chemicals found in the American paw paw. . . Graviola Max delivers almost four times more acetogenins than paw paw! See a comparison of the acteogenins chemicals in all three plants.
For more complete information on these power plants of the rainforest, please see the Database file on Graviola. These graviola plants have been sustainably harvested in the Amazon Rainforest. Click here to learn more about our rainforest ingredients and wild harvesting methods. This product contains no binders, fillers, or exipients and is 100% finely milled natural plants. This product is backed by Raintree's Unconditional Guarantee.
Ingredients: A proprietary blend of graviola leaf and stem (Annona muricata), and mountain graviola leaf and stem (Annona montana). No binders, fillers, or additives are used—just 100% pure plants, rich in the naturally occurring plant chemicals that these plants are regarded for.
Suggested Use: Take 3 capsules 3-4 times or as directed by a healthcare professional.
Contraindications:
Not to be used during pregnancy or breast-feeding.
Graviola has demonstrated hypotensive, vasodilator, and cardiodepressant activities in animal studies. People with low blood pressure should monitor their blood pressure accordingly.
Drug Interactions: None have been reported; however, based on animal studies, graviola may potentiate antihypertensive and cardiac depressant drugs.
Other Observations:
Graviola has demonstrated in vitro antimicrobial properties. Chronic, long-term use of this plant might lead to some die-off of friendly bacteria in the digestive tract. Supplementing the diet with probiotics and digestive enzymes may be helpful
to counteract this possible effect.
Graviola has demonstrated emetic properties in one animal study with pigs. Large single dosages may cause nausea or vomiting. Reduce the usage accordingly or take with a meal if nausea occurs.
Drinking plenty of water (at least 8 glasses a day) is helpful to reduce Herxheimer reactions and flush dead and dying cells from the body.
One of three documented mechanisms of action of graviola is by decreasing energy to abnormal cells (called an ATP-inhibitor). Taking supplements that increase cellular energy (like CoQ10) will counteract or disable this one mechanism of action of graviola (however, the other two mechanisms of action will be unaffected).
A 120 capsule bottle is $21.95 each
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Third-Party Published Research*
This Raintree product has not been the subject of any clinical research.
All available third-party research on these graviola plants can be found at PubMed/Medline.
A partial listing of the published research on these graviola plants are shown below:
Graviola (Annona muricata) Takahashi, J. A., et al. “Antibacterial activity of eight Brazilian Annonaceae plants.” Nat. Prod. Res. 2006; 20(1): 21-6.
Kojima, N. “Systematic synthesis of antitumor Annonaceous acetogenins” Yakugaku Zasshi. 2004; 124(10): 673-81
Yuan, S. S., et al. “Annonacin, a mono-tetrahydrofuran acetogenin, arrests cancer cells at the G1 phase and causes
cytotoxicity in a Bax- and caspase-3-related pathway.” Life Sci. 2003 May: 72(25): 2853-61.
Liaw, C. C., et al. “New cytotoxic monotetrahydrofuran Annonaceous acetogenins from Annona muricata.” J. Nat. Prod.
2002; 65(4): 470-75.
Gonzalez-Coloma, A., et al. “Selective action of acetogenin mitochondrial complex I inhibitors.” Z. Naturforsch. 2002;
57(11-12): 1028-34.
Chang, F. R., et al. “Novel cytotoxic Annonaceous acetogenins from Annona muricata.” J. Nat. Prod. 2001; 64(7): 925-31.
Padma, P., et al. “Effect of Annona muricata and Polyalthia cerasoides on brain neurotransmitters and enzyme
monoamine oxidase following cold immobilization stress.” J. Natural Remedies 2001; 1(2): 144-46.
Jaramillo, M. C., et al. “Cytotoxicity and antileishmanial activity of Annona muricata pericarp.” Fitoterapia. 2000; 71 (2):
183-6.
Betancur-Galvis, L., et al. “Antitumor and antiviral activity of Colombian medicinal plant extracts.” Mem. Inst. Oswaldo
Cruz. 1999; 94(4): 531-35.
Kim, G. S., et al. “Muricoreacin and murihexocin C, mono-tetrahydrofuran acetogenins, from the leaves of Annona
muricata.” Phytochemistry. 1998; 49(2): 565-71.
Kim, G. S., et al. “Two new mono-tetrahydrofuran ring acetogenins, annomuricin E and muricapentocin, from the leaves
of Annona muricata.” J. Nat. Prod. 1998; 61(4): 432-36.
Nicolas, H., et al. “Structure-activity relationships of diverse Annonaceous acetogenins against multidrug resistant human
mammary adenocarcinoma (MCF-7/Adr) cells.” J. Med. Chem. 1997; 40(13): 2102-6.
Zeng, L., et al. “Five new monotetrahydrofuran ring acetogenins from the leaves of Annona muricata.” J. Nat. Prod. 1996;
59(11): 1035-42.
Wu, F. E., et al. “Two new cytotoxic monotetrahydrofuran Annonaceous acetogenins, annomuricins A and B, from the
leaves of Annona muricata.” J. Nat. Prod. 1995; 58(6): 830-36.
Wu, F. E., et al. “Additional bioactive acetogenins, annomutacin and (2,4-trans and cis)-10R-annonacin-A-ones, from the
leaves of Annona muricata.” J. Nat. Prod. 1995; 58(9): 1430-37.
Wu, F. E., et al. “New bioactive monotetrahydrofuran Annonaceous acetogenins, annomuricin C and muricatocin C, from
the leaves of Annona muricata.” J. Nat. Prod. 1995; 58(6): 909-5.
Wu, F. E., et al. “Muricatocins A and B, two new bioactive monotetrahydrofuran Annonaceous acetogenins from the
leaves of Annona muricata.” J. Nat. Prod. 1995; 58(6): 902-8.
Sundarrao, K., et al. “Preliminary screening of antibacterial and antitumor activities of Papua New Guinean native
medicinal plants.” Int. J. Pharmacog. 1993; 31(1): 3-6.
Heinrich, M., et al. “Parasitological and microbiological evaluation of Mixe Indian medicinal plants (Mexico).” J.
Ethnopharmacol. 1992; 36(1): 81–5.
Mountain Graviola (Annona montana) Liaw, C. C., et al. “Novel cytotoxic monotetrahydrofuranic Annonaceous acetogenins from Annona montana.” Bioorg.
Med. Chem. 2005 Aug; 13(15): 4767-76.
Tormo, J. R., et al. “In vitro antitumor structure-activity relationships of threo/trans/threo/trans/erythro
bis-tetrahydrofuranic acetogenins: correlations with their inhibition of mitochondrial complex I.” Oncol. Res. 2005; 15(3):
129-38.
Liaw, C. C., et al. “Montacin and cis-montacin, two new cytotoxic monotetrahydrofuran Annonaceous acetogenins from
Annona montana.” J. Nat. Prod. 2004; 67(11): 1804-8.
Liaw, C. C., et al. “Nine new cytotoxic monotetrahydrofuranic Annonaceous acetogenins from Annona montana.” Planta
Med. 2004; 70(10): 948-59.
Kojima, N. “Systematic synthesis of antitumor annonaceous acetogenins.” Yakugaku Zasshi. 2004; 124(10): 673-81
Wang, L. Q., et al. “Annonaceous acetogenins from the leaves of Annona montana.” Bioorg. Med. Chem. 2002; 10(3):
561-5.
Wang, L. Q., et al. “Cytotoxic mono-tetrahydrofuran ring acetogenins from leaves of Annona montana.” Planta Med. 2001
Dec; 67(9): 847-52.
Mootoo, B. S., et al. “Three novel monotetrahydrofuran annonaceous acetogenins from Annona montana.”J. Nat. Prod.
2000; 63(6): 807-11.
Yang, S., et al. “Chemical constituents of Annonaceae plants and their antitumor activities.” Zhongguo Yi. Xue. Ke. Xue.
Yuan. Xue. Bao. 2000 Aug; 22(4): 376-82.
Wang, L. Q., et al. “Four mono-tetrahydrofuran ring acetogenins, montanacins B-E, from Annona montana.” Chem.
Pharm. Bull. 2000; 48(8): 1109-13.
Wu, Y. C., et al. “Bioactive constitutents from the stems of Annona montana.” Planta Med. 1995 Apr; 61(2): 146-9.
Jossang, A., et al. “Annomonysvin: a new cytotoxic gamma-lactone-monotetrahydrofuranyl acetogenin from Annona
montana.” J. Nat. Prod. 1991 Jul-Aug; 54(4): 967-71.
RELATED PRODUCTS:
Graviola can be found as an ingredient in these proprietary Raintree formulas:
Graviola Tech Report -- A FREE Technical Plant Data Report is available for graviola.
* The statements contained herein have not been evaluated by the Food and Drug Administration.
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