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Amazon
CNS SUPPORT*
120 capsules (650 mg each)
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A synergistic formula of 6 rainforest botanicals traditionally used in South America to support the central nervous system and calm pain processing pathways.* For more information on the individual ingredients in Amazon CNS Support, follow the links provided below to the plant database files in the Tropical Plant Database.
Each rainforest botanical in this professional formula has been sustainably harvested in the Amazon Rainforest. Click here to learn more about our rainforest ingredients and wild harvesting methods. This product contains no binders, fillers, or exipients and is 100% finely milled natural plants. This product is backed by Raintree's Unconditional Guarantee.
Ingredients: A proprietary blend of pau d'arco, tayuya, manacá, mulungu, amor seco, and iporuru.
This formula is 100% pure natural ground plants. No binders, fillers or other additives are used. These plants have grown naturally in the richness of the Amazon without any pesticides or fertilizers and they are non-irradiated and non-fumigated.
Suggested Use: Take 2-3 capsules every 4-6 hours as needed.
Contraindications:
- Not to be used during pregnancy or while breast-feeding.
- Manacá has documented anticoagulant activity. People with blood disorders such as hemophilia should be monitored closely for this possible effect.
Drug Interactions: May potentiate anticoagulants, MAO-inhibitors and antihypertensive medications.
Other Practitioner Observations:
- Manacá contains salicylate. Those with an allergy or sensitivity to salicylates or aspirin may be sensitive to this formula.
- This formula may cause drowsiness at higher dosages. If this occurs; reduce the amount used.
- Plants in this formula may reduce blood pressure (based on animal studies). Those with low blood pressure should be monitored for this possible effect.
A 120 capsule bottle is $29.95 each
Or buy 3 bottles for $28.95 each
Or buy 6 bottles for $26.95 each
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Print a PDF Amazon CNS Support Brochure
Please note that this is a professional product offered by health practitioners and it is not available in retail stores. Click here to see a list of practitioners who use our products.
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Third-Party Published Research*
This proprietary Raintree product has not been the subject of any clinical research. A partial listing of third-party published research on each herbal ingredient in the formula is shown below. Please refer to the plant database files by clicking on the plant names below to see all available documentation and research on each plant ingredient.
Pau d'arco (Tabebuia impetiginosa)
de Miranda, F. G., et al. “Antinociceptive and antiedematogenic properties and acute toxicity of Tabebuia
avellanedae Lor. ex Griseb. inner bark aqueous extract.” BMC. Pharmacol. 2001; 1(1): 6.
Awale, S., et al. ”Nitric oxide (NO) production inhibitory constituents of Tabebuia avellanedae from Brazil.”
Chem. Pharm. Bull. 2005; 53(6): 710-3.
Oga, S., et al. “Toxicidade e atividade anti-inflamatoria de Tabebuia avellanedae Lorentz (‘Ipe Roxo’).” Rev.
Fac. Farm. Bioquim. 1969; 7: 4.
Tayuya (Cayaponia tayuya)
Escandell, J. M., et al. “Dihydrocucurbitacin B, isolated from Cayaponia tayuya, reduces damage in adjuvant-
induced arthritis.” Eur. J. Pharmacol. 2006 Jan 26;
Recio, M. C., et al. “Anti-inflammatory activity of two cucurbitacins isolated from Cayaponia tayuya roots.”
Planta Med. 2004; 70(5): 414-20.
Himeno, E., et al. “Structures of cayaponosides A, B, C and D, glucosides of new nor-cucurbitacins in the roots
of Cayaponia tayuya.” Chem. Pharm. Bull. (Tokyo) 1992; 40(10): 2885–87.
Ruppelt, B. M., et al. “Pharmacological screening of plants recommended by folk medicine as anti-snake
venom—I. Analgesic and anti-inflammatory activities.” Mem. Inst. Oswaldo Cruz 1991; 86 (Suppl. 2): 203–5.
Rios, J. L., et al. “A study of the anti-inflammatory activity of Cayaponia tayuya root.” Fitoterapia 1990; 61(3):275–78.
Faria, M. R. and E. P. Schenkel. “Caracterizacao de cucurbitacinas em especies vegetais cohecidas
popularmente como taiuiá.” Ciencia e Cultura (São Paulo) 1987; 39: 970–73.
Bauer, R., et al. “Cucurbitacins and flavone C-glycosides from Cayaponia tayuya.” Phytochemisty. 1984:
1587–91.
Manacá (Brunfelsia uniflora)
Rollinger, J. M., et al. “Acetylcholinesterase inhibitory activity of scopolin and scopoletin discovered by virtual
screening of natural products.” J. Med. Chem. 2004 Dec 2; 47(25): 6248-54.
Park, J. H., et al. “Antiinflammatory activity of Synurus deltoides.” Phytother. Res. 2004; 18(11): 930-3.
Kim, H. J., et al. “Scopoletin suppresses pro-inflammatory cytokines and PGE2 from LPS-stimulated cell line,
RAW 264.7 cells.” Fitoterapia. 2004 Jun; 75(3-4): 261-6.
Ruppelt, B. M., et al. “Pharmacological screening of plants recommended by folk medicine as anti-snake
venom–I. Analgesic and anti-inflammatory activities.” Mem. Inst. Oswaldo Cruz 1991; 86: 203–5.
Iyer, R. P., et al. “Brunfelsia hopeana I: Hippocratic screening and antiinflammatory evaluation." Lloydia. 1977;
40(4): 356–60.
de Costa, A. O. “A pharmacologic study of manacá (Brunfelsia hopeana)." Bol. Assoc. Bras. Pharm. 1933; 14:
295–99.
Mulungu (Erythrina mulungu)
Marchioro, M., et al. “Anti-nociceptive activity of the aqueous extract of Erythrina velutina leaves.” Fitoterapia.
2005 Dec; 76(7-8): 637-42.
Chaddock, J. A., et al. “Retargeted clostridial endopeptidases: inhibition of nociceptive neurotransmitter release
in vitro, and antinociceptive activity in in vivo models of pain.” Mov. Disord. 2004 Mar; 19 Suppl 8: S42-7.
Weber, D., et al. “Phomol, a new antiinflammatory metabolite from an endophyte of the medicinal plant
Erythrina crista-galli.” J. Antibiot. 2004; 57(9): 559-63.
Vasconcelos, S. M., et al. “Antinociceptive activities of the hydroalcoholic extracts from Erythrina velutina and
Erythrina mulungu in mice.” Biol. Pharm. Bull. 2003; 26(7): 946-9.
Njamen, D., et al. “Anti-inflammatory activity of erycristagallin, a pterocarpene from Erythrina mildbraedii.”
Eur. J. Pharmacol. 2003 May; 468(1): 67-74.
Duggan, M. J., et al. “Inhibition of release of neurotransmitters from rat dorsal root ganglia by a novel conjugate
of a Clostridium botulinum toxin A endopeptidase fragment and Erythrina crista-galli lectin.” J. Biol. Chem.
2002 Sep; 277(38): 34846-52.
Amor Seco (Desmodium adscendens)
N’Gouemo, P., et al. “Effects of an ethanolic extract of Desmodium adscendens on central nervous system in
rodents.” J. Ethnopharmacol. 1996; 52(2): 77–83.
McManus, O. B., et al. “An activator of calcium-dependent potassium channels isolated from a medicinal herb.”
Biochemistry 1993; 32(24): 6128–33.
Addy, M. E., et al. “Some secondary plant metabolites in Desmodium adscendens and their effects on
arachidonic acid metabolism.” Prostaglandins Leukotrienes Essent. Fatty Acids 1992; 47(1): 85–91.
Boye, G. and O. Ampopo. “Plants and traditional medicine in Ghana.” Economic and Medicinal Plant Research
4 1990. Devon, England: Academic Press Ltd.: 33–4.
Addy, M. E., et al. “Effect of Desmodium adscendens fraction 3 on contractions of respiratory smooth muscle.”
J. Ethnopharmacol. 1990; 29(3): 325–35.
Iporuru (Alchornea castaneifolia)
Manga, H.M., et al. “In vivo anti-inflammatory activity of Alchornea cordifolia (Schumach. & Thonn.) Mull. Arg.
(Euphorbiaceae).” J. Ethnopharmacol. 2004 Jun; 92(2-3): 209-14.
Osadebe, P. O., et al. “Anti-inflammatory effects of crude methanolic extract and fractions of Alchornea
cordifolia leaves.” J. Ethnopharmacol. 2003 Nov; 89(1):19-24.
Tona, L., et al. “Antiamoebic and spasmolytic activities of extracts from some antidiarrhoeal traditional
preparations used in Kinshasa, Congo.” Phytomedicine. 2000 Mar; 7(1): 31-8.
Dunstan, C. A., et al. “Evaluation of some Samoan and Peruvian medicinal plants by prostaglandin
biosynthesis and rat ear oedema assays.” J. Ethnopharmacol. 1997; 57: 35–56.
Ogungbamila, F. O., et al. “Smooth muscle–relaxing flavonoids from Alchornea cordifolia.” Acta Pharm. Nord.
1990; 2(6): 421–22.
Persinos-Perdue, G., et al. “Evaluation of Peruvian folk medicine by the natural products research
laboratories.” Abstra. Joint Meeting American Society of Pharmacognosy and Society for Economic Botany,
Boston, 1981; (5) 13
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* The statements contained herein have not been evaluated
by the Food and Drug Administration.
This product is
not intended to treat, cure, mitigate or prevent any disease.
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3579 Hwy 50 East, Suite 222
Carson City, NV 89701
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(775) 841-4142
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Updated 12-31-06
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