This proprietary Raintree product has not been the subject of any clinical research. A partial listing of third-party published research on each herbal ingredient in the formula is shown below. Please refer to the plant database files by clicking on the plant names below to see all available documentation and research on each plant ingredient.

Cat's Claw (Uncaria tomentosa)
Erowele, G., et al. "Pharmacology and therapeutic uses of cat's claw." Am. J. Health Syst. Pharm. 2009 Jun 1; 66(11): 992-5.
Reis, S., et al. "Immunomodulating and antiviral activities of Uncaria tomentosa on human monocytes infected with Dengue Virus-2." Int. Immunopharmacol. 2008; 8(3): 468-76.
Holderness, J., et al. "Select plant tannins induce IL-2Ralpha up-regulation and augment cell division in gammadelta T cells." J. Immunol. 2007 Nov; 179(10): 6468-78.
Groom, S., et al. "The potency of immunomodulatory herbs may be primarily dependent upon macrophage activation." J. Med. Food. 2007 Mar; 10(1): 73-9.
Spelman, K., et al. "Modulation of cytokine expression by traditional medicines: a review of herbal immunomodulators." Altern. Med. Rev. 2006 Jun; 11(2): 128-50.
Allen-Hall, L., et al. "Treatment of THP-1 cells with Uncaria tomentosa extracts differentially regulates the expression if IL-1beta and TNF-alpha." J. Ethnopharmacol. 2007 Jan; 109(2): 312-7.
Cisneros, F. J., et al. “An Uncaria tomentosa (cat's claw) extract protects mice against ozone-induced lung inflammation.” J. Ethnopharmacol. 2005 Jan; 96(3): 355-64.
Eberlin, S., et al. “Uncaria tomentosa extract increases the number of myeloid progenitor cells in the bone marrow of mice infected with Listeria monocytogenes.” Int. Immunopharmacol. 2005; 5(7-8):1235-46.
Deharo, E., et al. ”In vitro immunomodulatory activity of plants used by the Tacana ethnic group in Bolivia.” Phytomedicine. 2004 Sep; 11(6): 516-22.
Lamm, S., et al, “Persistent response to pneumococcal vaccine in individuals supplemented with a novel water soluble extract of Uncaria tomentosa, C-Med-100." Phytomedicine. 2001; 8(4): 267–74.
Sheng Y, et al., “Treatment of chemotherapy-induced leukopenia in a rat model with aqueous extract from Uncaria tomentosa.” Phytomedicine. 2000; 7(2): 137–43.
Sandoval, M., et al. “Cat’s claw inhibits TNFalpha production and scavenges free radicals: role in cytoprotection.” Free Radic. Biol. Med. 2000; 29(1): 71–8.
Sheng, Y., et al. “Enhanced DNA repair, immune function and reduced toxicity of C-Med-100, a novel aqueous extract from Uncaria tomentosa." J. Ethnopharmacol. 2000; 69(2): 115–26.
Lemaire, I., et al. “Stimulation of interleukin-1 and -6 production in alveolar macrophages by the neotropical liana, Uncaria tomentosa (una de gato).” J. Ethnopharmacol. 1999; 64(2): 109–15.
Marina, M. D. “Evaluacion de la actividal immunoestimulante de Uncaria tomentosa (Willd.) DC. Una de gato en ratones albinos." Biodiversidad Salud. 1998; 1(1): 16–19.
Keplinger, H., et al. “Oxindole alkaloids having properties stimulating the immunologic system and preparation containing same.” United States patent 5,302,611; April 12, 1994.
Sheng, Y., et al. “DNA repair enhancement of aqueous extracts of Uncaria tomentosa in a human volunteer study." Phytomedicine. 2001; 8(4): 275–82.

Anamu (Petiveria alliacea)
Queiroz, M. L., et al. “Cytokine profile and natural killer cell activity in Listeria monocytogenes infected mice treated orally with Petiveria alliacea extract. Immunopharmacol. Immunotoxicol. 2000 Aug; 22(3): 501-18.
Quadros, M. R., et al. “Petiveria alliacea L. extract protects mice against Listeria monocytogenes infection—effects on bone marrow progenitor cells.” Immunopharmacol. Immunotoxicol. 1999 Feb; 21(1): 109-24.
Williams, L., et al. “Immunomodulatory activities of Petiveria alliaceae L.” Phytother. Res. 1997; 11(3): 251253.
Rossi, V., “Effects of Petiveria alliacea L. on cell immunity.” Pharmacol. Res. 1993; 27(1): 111-12.
Marini, S., “Effects of Petiveria alliacea L. on cytokine production and natural killer cell activity.” Pharmacol. Res. 1993; 27(1): 107-08.

Mullaca (Physalis angulata)
Soares, M. B., et al. “Physalins B, F and G, seco-steroids purified from Physalis angulata L., inhibit lymphocyte function and allogeneic transplant rejection.” Int. Immunopharmacol. 2006; 6(3): 408-14.
Garcia, E. S., et all. “Trypanosoma rangeli: effects of physalin B on the immune reactions of the infected larvae of Rhodnius prolixus.” Exp. Parasitol. 2006; 112(1): 37-43.
Soares, M. B., et al. “Inhibition of macrophage activation and lipopolysaccaride-induced death by seco-steroids purified from Physalis angulata L.” Eur. J. Pharmacol. 2003; 459(1): 107-12.
Lin, Y. S., et al. “Immunomodulatory activity of various fractions derived from Physalis angulata L. extract.” Amer. J. Chinese Med. 1992; 20(3/4): 233–43.
Shingu, K., et al. “Three new withanolides, physagulins E, F and G from Physalis angulata L." Chem. Pharm. Bull. 1992; 40(9): 2448–51.

Fedegoso (Cassia occidentalis)
Bin-Hafeez, B., et al. "Protective effect of Cassia occidentalis L. on cyclophosphamide-induced suppression of humoral immunity in mice." J. Ethnopharmacol. 2001; 75(1): 13-18.
Sharma, N., et al. “In vitro inhibition of carcinogen-induced mutagenicity by Cassia occidentalis and Emblica officinalis.” Drug Chem. Toxicol. 2000; 23(3): 477–84.
Sharma, N., et al. “Protective effect of Cassia occidentalis extract on chemical-induced chromosomal aberrations in mice.” Drug Chem. Toxicol. 1999; 22(4): 643–53.

Sarsaparilla (Smilax officinalis)
Chu, K. T., et al. “Smilaxin, a novel protein with immunostimulatory, antiproliferative, and HIV-1-reverse transcriptase inhibitory activities from fresh Smilax glabra rhizomes.” Biochem. Biophys. Res. Commun. 2005 Dec; 340(1): 118.
Jiang, J., et al. "Immunomodulatory activity of the aqueous extract from rhizome of Smilax glabra in the later phase of adjuvant-induced arthritis in rats." J. Ethnopharmacol. 2003; 85(1): 53-9.
Chen, T., et al. "A new flavanone isolated from Rhizoma smilacis glabrae and the structural requirements for its derivatives for preventing immunological hepatocyte damage." Planta Med. 1999; 65(1): 56-9.
Ma, D., et al. ”Effect of sarsasapogenin and its derivatives on the stimulus coupled responses of human neutrophils.” Clin. Chim. Acta. 2001 Dec; 314(1-2): 107-12.

Samambaia (Polypodium sp.)
Reyes, E., et al. “Systemic immunomodulatory effects of Polypodium leucotomos as an adjuvant to PUVA therapy in generalized vitiligo: A pilot study.” J. Dermatol. Sci. 2006; 41(3): 213-6.
Nogal-Ruiz, J. J., “Modulation by Polypodium leucotomos extract of cytokine patterns in experimental trichomoniasis model.” Parasite. 2003 Mar; 10(1): 73-8.
Sempere-Ortells, J. M., et al. “Anapsos (Polypodium leucotomos) modulates lymphoid cells and the expression of adhesion molecules.” Pharmacol. Res. 2002; 46(2): 185–90.
Gonzalez, S., et al. “An extract of the fern Polypodium leucotomos (Difur) modulates Th1/Th2 cytokines balance in vitro and appears to exhibit anti-angiogenic activities in vivo: Pathogenic relationships and therapeutic implications.” Anticancer Res. 2000; 20(3a): 1567–75.
Sempere-Ortells , J. M., et al. “Effect of Anapsos (Polypodium leucotomos extract) on in vitro production of cytokines.” Br. J. Clin. Pharmacol. 1997; 43(1): 85–9.
Bernd, A., et al. “In vitro studies on the immunomodulating effects of Polypodium leucotomos extract on human leukocyte fractions.” Arzneimittelforschung. 1995; 45(8): 901–4.
Rayward, J. et al. ”Polypodium leucotomos (PL), an herbal extract, inhibits the proliferative response of T. lymphocytes to polyclonal mitogens.” Second Intl. Cong. on Biol. Response Modifiers, San Diego, U.S.A. 1993.
Tuominen, M., et al., “Enhancing effect of extract Polypodium leucotomos on the prevention of rejection on skin transplants” Phytotherapy Research 1991; 5: 234–37.

Macela (Achyrocline satureoides)
Santos, A. L., et al. “Immunomodulatory effect of Achyrocline satureioides (Lam.) D.C. aqueous extracts.” Phytother. Res. 1999; 13(1):65–66.
Puhlmann J, et al. “Immunologically active metallic ion-containing polysaccharides of Achyrocline satureioides.” Phytochemistry. 1992; 31(8): 2617-21.
Wagner, H., et al. “Immunostimulating polysaccharides (heteroglycanes) of higher plants.” Arzneimforsch. 1985; 35(7): 1069–75.
Wagner, H., et al. “Immunostimulating polysaccharides (heteroglycanes) of higher plants/preliminary communication.” Arzneimforsch. 1984; 34(6): 659–61.
Arredondo, M. F., et al. “Cytoprotection by Achyrocline satureioides (Lam) D.C. and some of its main flavonoids against oxidative stress.” J. Ethnopharmacol. 2004 Mar; 91(1): 13-20.