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Amazon
JOINT-MUSCLE SUPPORT*
120 capsules (650 mg each)
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A powerful formula of 8 rainforest botanicals which have been traditionally used in South America for joints and muscles.* For more information on the individual ingredients in Amazon Joint-Muscle Support, follow the links provided below to the plant database files in the Tropical Plant Database.
Each rainforest botanical in this professional formula has been sustainably harvested in the Amazon Rainforest. Click here to learn more about our rainforest ingredients and wild harvesting methods. This product contains no binders, fillers, or exipients and is 100% finely milled natural plants. This product is backed by Raintree's Unconditional Guarantee.
Ingredients: A proprietary blend of cat's claw, chuchuhuasi, amor seco, tayuya, picão preto, iporuru, sarsaparilla, and guaco. This formula is 100% pure natural ground plants. No binders, fillers or other additives are used. These plants have grown naturally in the richness of the Amazon without any pesticides or fertilizers and they are non-irradiated and non-fumigated.
Suggested Use: Take 2-3 capsules every 4-6 hours as needed.
Contraindications: - Not to be used during pregnancy or while breast-feeding.
- Several plants in this formula contain coumarin which has an anticoagulant effect. Individuals with blood disorders such as hemophilia, or those on blood thinning medications should be monitored for this effect.
- This product should not be used with medications intended to suppress the immune system.
Drug Interactions: May potentiate anticoagulants such as Warfarin®. May reduce the effect of immune suppressive medications. May enhance the effect of antihypertensive medications.
Other Practitioner Observations: - Picão preto contains a small amount of naturally occurring caffeine. Those individuals sensitive or allergic to caffeine should avoid this formula.
- Cat's claw has been documented to have an anti-fertility effect. Those seeking to become pregnant or those undergoing treatment for infertility should consult their doctor prior to use.
A 120 capsule bottle is $29.95 each
Or buy 3 bottles for $28.95 each
Or buy 6 bottles for $26.95 each
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Print a PDF Amazon Joint-Muscle Support Brochure
Please note that this is a professional product offered by health practitioners and it is not available in retail stores. Click here to see a list of practitioners who use our products.
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Third-Party Published Research*
This proprietary Raintree product has not been the subject of any clinical research. A partial listing of third-party published research on each herbal ingredient in the formula is shown below. Please refer to the plant database files by clicking on the plant names below to see all available documentation and research on each plant ingredient.
Cat's Claw (Uncaria tomentosa)
Hardin, S. R. "Cat's claw: An Amazonian vine decreases inflammation in osteoarthritis." Complement. Ther. Clin. Pract. 2007 Feb; 13(1): 25-8.
Miller, M. J., et al. "Early relief of osteoarthritis symptoms with a natural mineral supplement and a herbomineral combination: a randomized controlled trial." J. Inflamm. 2005 Oct; 2:11.
Miller, M. J., et al. "The chrondoprotective actions of a natural product are associated with the activation of IGF-1 production by human chondrocytes despite the presence of IL-1beta." BMC Complement. Altern. Med. 2006 Apr; 6: 13.
Setty, A. R., et al. "Herbal medications commonly used in the practice of rheumatology: mechanisms of action, efficacy, and side effects." Semin. Arthritis Rheum. 2005; 34(6): 773-84.
Aguilar, J. L., et al. “Anti-inflammatory activity of two different extracts of Uncaria tomentosa (Rubiaceae).” J.
Ethnopharmacol. 2002; 81(2): 271–76.
Sandoval, M., et al., “Anti-inflammatory and antioxidant activities of cat’s claw (Uncaria tomentosa and Uncaria
guianensis) are independent of their alkaloid content." Phytomedicine. 2002; 9(4): 325–37.
Mur, E., et al. “Randomized double blind trial of an extract from the pentacyclic alkaloid-chemotype of Uncaria
tomentosa for the treatment of rheumatoid arthritis.” J. Rheumatol. 2002 Apr; 29(4): 678–81.
Piscoya, J., et al. “Efficacy and safety of freeze-dried cat's claw in osteoarthritis of the knee: mechanisms of
action of the species Uncaria guianensis.” Inflamm. Res. 2001; 50(9): 442-8.
Sandoval-Chacon, M., et al. “Anti-inflammatory actions of cat’s claw: the role of NF-kappaB.” Aliment. Pharmacol. Ther. 1998; 12(12): 1279–89.
Recio, M. C., et al. “Structural requirements for the anti-inflammatory activity of natural triterpenoids.” Planta Med. 1995; 61(2): 182–85.
Aquino, R., et al. “Plant metabolites. New compounds and anti-inflammatory activity of Uncaria tomentosa." J. Nat. Prod. 1991; 54: 453–59.
Cerri, R., et al. “New quinovic acid glycosides from Uncaria tomentosa." J. Nat. Prod. 1988; 51: 257–61.
Mur, E., et al. "Randomized double blind trial of an extract from the pentacyclic alkaloid-chemotype of Uncaria tomentosa for the treatment of rheumatoid arthritis. J. Rheumatol. 2002; 29(4): 678-81.
Chuchuhuasi (Maytenus krukovii, laevis)
Sosa, S., et al. "Anti-inflammatory activity of Maytenus senegalensis root extracts and of maytenoic acid." Phytomedicine. 2007 Feb; 14(2-3): 109-14.
Honda, T., et al. “Partial synthesis of krukovines A and B, triterpene ketones isolated from the Brazilian medicinal plant Maytenus krukovii.” J. Nat. Prod. 1997; 60(11): 1174-77.
Morita, H., et al. “Triterpenes from Brazilian medicinal plant “chuchuhuasi” (Maytenus krukovii).” J. Nat. Prod.
1996; 59(11): 1072-75.
Sekar K. V., et al. “Mayteine and 6-benzoyl-6-deacetyl-mayteine from Maytenus krukovii.” Planta Med. 1995; 61: 390.
Bradshaw, D., et al. “Therapeutic potential of protein kinase C inhibitors.” Agents and Actions 1993; 38: 135-47.
Itokawa, H., et al. “Isolation, structural elucidation and conformational analysis of sesquiterpene pyridine alkaloids from Maytenus ebenifolia Reiss. X-ray molecular structure of ebenifoline W-1.” J. Chem. Soc. Perkin. Trans. I 1993; 11: 1247-54.
Itokawa, H., et al. “Oligo-nicotinated sesquiterpene polyesters from Maytenus ilicifolia.” J. Nat. Prod. 1993; 56: 1479-85.
Gonzalez, J. G., et al. “Chuchuhuasha—a drug used in folk medicine in the Amazonian and Andean areas. A chemical study of Maytenus laevis.” J. Ethnopharm. 1982; 5: 73–7.
Moya, S., et al. “Phytochemical and pharmacological studies on the antiarthritics of plant origin.” Rev. Colomb. Cienc. Quim. Farm. 1977; 3(2): 5.
Amor Seco (Desmodium adscendens)
N’Gouemo, P., et al. “Effects of an ethanolic extract of Desmodium adscendens on central nervous system in
rodents.” J. Ethnopharmacol. 1996; 52(2): 77–83.
Addy, M. E., et al. “An extract of Desmodium adscendens activates cyclooxygenase and increases
prostaglandin synthesis by ram seminal vesicle microsomes.” Phytother. Res. 1995; 9(4): 287–93.
McManus, O. B., et al. "An activator of calcium-dependent potassium channels isolated from a medicinal herb."
Biochemistry 1993; 32(24): 6128-33.
Addy, M. E., et al. "Several chromatographically distinct fractions of Desmodium adscendens inhibit smooth
muscle contractions." Int. J. Crude Drug Res. 1989; 27(2): 81-91.
Addy, M. E., et al. "Some secondary plant metabolites in Desmodium adscendens and their effects on
arachidonic acid metabolism." Prostaglandins Leukotrienes Essent. Fatty Acids 1992; 47(1): 85-91.
Addy, M. E., et al. "Effect of Desmodium adscendens fractions on antigen- and arachidonic acid-induced
contractions of guinea pig airways." Can. J. Physiol. Pharmacol. 1987; 66(6): 820-25.
Tayuya (Cayaponia tayuya)
Escandell, J. M., et al. “Dihydrocucurbitacin B, isolated from Cayaponia tayuya, reduces damage in adjuvant-induced arthritis.” Eur. J. Pharmacol. 2006 Feb; 532(1-2): 145-54.
Escandell, J. M., et al. "Cucurbitacin R reduces the inflammation and bone damage associated with adjuvant arthritis in Lewis rats by suppression of TNF-{alpha} in T lymphocytes and macrophages." J. Pharmacol. Exp. Ther. 2006 Feb; 532(1-2): 145-54.
Recio, M. C., et al. “Anti-inflammatory activity of two cucurbitacins isolated from Cayaponia tayuya roots.” Planta Med. 2004; 70(5): 414-20.
Himeno, E., et al. “Structures of cayaponosides A, B, C and D, glucosides of new nor-cucurbitacins in the roots of Cayaponia tayuya.” Chem. Pharm. Bull. 1992; 40(10): 2885–87.
Ruppelt, B. M., et al. “Pharmacological screening of plants recommended by folk medicine as anti-snake venom—I. Analgesic and anti-inflammatory activities.” Mem. Inst. Oswaldo Cruz 1991; 86 (Suppl. 2): 203–5.
Rios, J. L., et al. “A study of the anti-inflammatory activity of Cayaponia tayuya root.” Fitoterapia 1990; 61(3):275–78.
Faria, M. R. and E. P. Schenkel. “Caracterizacao de cucurbitacinas em especies vegetais cohecidas popularmente como taiuiá.” Ciencia e Cultura (São Paulo) 1987; 39: 970–73.
Bauer, R., et al. “Cucurbitacins and flavone C-glycosides from Cayaponia tayuya.” Phytochemisty. 1984: 1587–91.
Picão Preto (Bidens pilosa)
Yoshida, N., et al. "Bidens pilosa suppresses interleukin-1beta-induced cyclooxygenase-2 expression through the inhibition of mitogen activated protein kinases phosphorylation in normal human dermal fibroblasts." J. Dermatol. 2006; 33(10): 676-83.
Chiang, Y. M., et al. “Ethyl caffeate suppresses NF-kappaB activation and its downstream inflammatory mediators, iNOS, COX-2, and PGE2 in vitro or in mouse skin.” Br. J. Pharmacol. 2005 Oct; 146(3): 352-63.
Nguelefack, T. B., et al. “Relaxant effects of the neutral extract of the leaves of Bidens pilosa Linn on isolated rat vascular smooth muscle.” Phytother. Res. 2005; 19(3): 207-10.
Chang, C. L., et al. "The distinct effects of a butanol fraction of Bidens pilosa plant extract on the development of Th1-mediated diabetes and Th2-mediated air way inflammation in mice." J. Biomed. Sci. 2005; 12(1): 79-89.
Pereira, R. L., et al. “Immunosuppressive and anti-inflammatory effects of methanolic extract and the polyacetylene isolated from Bidens pilosa L.” Immunopharmacology. 1999; 43(1): 31–7.
Jager, A. K., et al. “Screening of Zulu medicinal plants for prostaglandin-synthesis inhibitors” J. Ethnopharmacol. 1996; 52(2): 95–100.
Chih, H. W., et al. “Anti-inflammatory activity of Taiwan folk medicine ‘ham-hong-chho’ in rats.” Am. J. Chin. Med. 1995; 23(3–4): 273–78.
Iporuru (Alchornea castaneifolia)
Manga, H.M., et al. “In vivo anti-inflammatory activity of Alchornea cordifolia (Schumach. & Thonn.) Mull. Arg.
(Euphorbiaceae).” J. Ethnopharmacol. 2004 Jun; 92(2-3): 209-14.
Osadebe, P. O., et al. “Anti-inflammatory effects of crude methanolic extract and fractions of Alchornea
cordifolia leaves.” J. Ethnopharmacol. 2003 Nov; 89(1):19-24.
Tona, L., et al. “Antiamoebic and spasmolytic activities of extracts from some antidiarrhoeal traditional
preparations used in Kinshasa, Congo.” Phytomedicine. 2000 Mar; 7(1): 31-8.
Dunstan, C. A., et al. “Evaluation of some Samoan and Peruvian medicinal plants by prostaglandin
biosynthesis and rat ear oedema assays.” J. Ethnopharmacol. 1997; 57: 35–56.
Ogungbamila, F. O., et al. “Smooth muscle–relaxing flavonoids from Alchornea cordifolia.” Acta Pharm. Nord.
1990; 2(6): 421–22.
Persinos-Perdue, G., et al. “Evaluation of Peruvian folk medicine by the natural products research
laboratories.” Abstra. Joint Meeting American Society of Pharmacognosy and Society for Economic Botany,
Boston, 1981; (5) 13
Sarsaparilla (Smilax officinalis)
Shao, B., et al. "Steroidal saponins from Smilax china and their anti-inflammatory activities." Phytochemistry. 2006 Dec 11;
Shu, X. S., et al. "The anti-inflammation effects of Smilax china ethylacetate extract in rats and mice." Zhongguo. Zhong. Yao. Za. Zhi. 2006 Feb; 31(3): 239-43.
Shu, X. S., et al. "Anti-inflammatory and anti-nociceptive activities of Smilax china L. aqueous extract." J. Ethnopharmacol. 2006 Feb; 103(3): 327-32.
Ji, W., et al. “Effects of Rebixiao granules on blood uric acid in patients with repeatedly attacking acute gouty arthritis.” Chin. J. Integr. Med. 2005 Mar; 11(1): 15-21.
Jiang, J., et al. “Immunomodulatory activity of the aqueous extract from rhizome of Smilax glabra in the later phase of adjuvant-induced arthritis in rats." J. Ethnopharmacol. 2003; 85(1): 53–9.
Ageel, A. M., et al. “Experimental studies on antirheumatic crude drugs used in Saudi traditional medicine.” Drugs Exp. Clin. Res. 1989; 15(8): 369–72.
Guaco (Mikania cordata, guaco)
Kontogiorgis, C., et al. "Antiinflammatory and antioxidant evaluation of novel coumarin derivatives." J. Enzyme. Inhib. Med. Chem. 2006 Feb; 21(1): 21-9.
Kontogiorgis, C., et al. "Synthesis and antiinflammatory activity of coumarin derivatives." J. Med. Chem. 2005 Oct; 48(20): 6400-8.
Suyenaga, E. S., et al. “Antiinflammatory investigation of some species of Mikania." Phytother. Res. 2002; 16(6): 519-23.
Ahmed, M., et al. “Analgesic sesquiterpene dilactone from Mikania cordata.” Fitoterapia. 2001 Dec; 72(8): 919-21.
Leal, L., et al. "Antinociceptive, anti-inflammatory and bronchodilator activities of Brazilian medicinal plants containing coumarin: a comparative study." J. Ethnopharmacol. 2000 May; 70(2): 151-9.
Peluso, G., et al. “Studies on the inhibitory effects of caffeoylquinic acids on monocyte migration and superoxide ion production.” J. Nat. Prod. 1995; 58(5): 639-46.
Leite, M. G. R., et al. “Actividade bronchodilatora de Mikania glomerata, Justicia pectoralis e Torresea cearensis." Simposio de Plantas Medicinais do Brazil. December 1992. Curitiba. Resumos. pp 21.
Oliveira, F., et al. “Caraterizacao cromatograpfica do extracto fluido de Mikania glomerata Sprengel.” Simposio de Plantas Medicinais do Brazil. December 1992. Curitiba. Resumos. pp 96.
Ruppelt, B. M., et al. “Pharmacological screening of plants recommended by folk medicine as anti-snake venom--I. Analgesic and anti-inflammatory activities.” Mem. Inst. Oswaldo Cruz. 1991; 86 Suppl 2:203-5.
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* The statements contained herein have not been evaluated
by the Food and Drug Administration.
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not intended to treat, cure, mitigate or prevent any disease.
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Updated 3-3-2007
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