Clinical References on Tayuya (Cayaponia tayuya)
Huguet AI, et al. Superoxide scavenging properties of flavonoids in a non-enzymic system. Z Naturforsch [C], 1990 Jan-Feb
(Abstract Available)
Konoshima T, et al. Inhibitory effects of cucurbitane triterpenoids on Epstein-Barr virus activation and two-stage carcinogenesis of skin tumor. II. Biol Pharm Bull, 1995 Feb
(Abstract Available)
Ruppelt BM, et al. Pharmacological screening of plants recommended by folk medicine as anti-snake venom--I. Analgesic and anti-inflammatory activities. Mem Inst Oswaldo Cruz, 1991
(Abstract Available)
Himeno E, et al. Structures of cayaponosides A, B, C and D, glucosides of new nor-cucurbitacins in the roots of Cayaponia tayuya. Chem Pharm Bull (Tokyo), 1992 Oct
Superoxide scavenging properties of flavonoids in a non-enzymic system.
Huguet AI; Máñez S; Alcaraz MJ
Departament de Farmacologia i Farmacotècnia, Facultat de Farmacia, Valencia, Spain.
Z Naturforsch [C], 45: 1-2, 1990 Jan-Feb, 19-24
Abstract
The superoxide anion scavenging activity of 38 flavonoids, some of them isolated from Sideritis mugronensis, Sideritis javalambrensis and Cayaponia tayuya were investigated by measurement of their inhibition of nitroblue tetrazolium reduction. Isoorientin, orientin, amentoflavone, leucocyanidol, eriodictyol, datiscetin and robinetin behaved as potent scavengers and structure-activity relationships were established.
Inhibitory effects of cucurbitane triterpenoids on Epstein-Barr virus activation and two-stage carcinogenesis of skin tumor. II.
Konoshima T; Takasaki M; Kozuka M; Nagao T; Okabe H; Irino N; Nakasumi T; Tokuda H; Nishino H
Kyoto Pharmaceutical University, Japan.
Biol Pharm Bull, 18: 2, 1995 Feb, 284-7
Abstract
To search for possible anti-tumor-promoters, we carried out a primary screening of twenty-four 29-nor-cucurbitacin glucosides isolated from the roots of Cayaponia tayuya (Cucurbitaceae) using an in vitro synergistic assay system. Of these glucosides, cayaponosides B (5), B3 (7), D (8), D3b (22) and C2 (23) exhibited significant inhibitory effects on Epstein-Barr virus (EBV) activation induced by the tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA). Furthermore, 5 and 23 exhibited remarkable anti-tumor-promoting effects on mouse skin tumor promotion in an in vivo two-stage carcinogenesis test.
Pharmacological screening of plants recommended by folk medicine as anti-snake venom--I. Analgesic and anti-inflammatory activities.
Ruppelt BM; Pereira EF; Gonçalves LC; Pereira NA
Departamento de Farmacologia, CCS-ICB, UFRJ, Ilha do Fundão, Rio de Janeiro, Brasil.
Mem Inst Oswaldo Cruz, 86 Suppl 2:1991, 203-5
Abstract
We have observed that several plants used popularly as anti-snake venom show anti-inflammatory activity. From the list prepared by Rizzini, Mors and Pereira some species have been selected and tested for analgesic activity (number of contortions) and anti-inflammatory activity (Evans blue dye diffusion--1% solution) according to Whittle's technique (intraperitoneal administration of 0.1 N-acetic acid 0.1 ml/10 g) in mice. Previous oral administration of a 10% infusion (dry plant) or 20% (fresh plant) corresponding to 1 or 2 g/kg of Apuleia leiocarpa, Casearia sylvestris, Brunfelsia uniflora, Chiococca brachiata, Cynara scolymus, Dorstenia brasiliensis, Elephantopus scaber, Marsypianthes chamaedrys, Mikania glomerata and Trianosperma tayuya demonstrated analgesic and/or anti-inflammatory activities of varied intensity.
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