Clinical References on Maracuja (Passiflora incarnata)
Wolfman C, et al. Possible anxiolytic effects of chrysin, a central benzodiazepine receptor ligand isolated from Passiflora coerulea. Pharmacol Biochem Behav, 1994 Jan
(Abstract Available)
Perry NB, et al. 4-Hydroxy-2-cyclopentenone: an anti-Pseudomonas and cytotoxic component from Passiflora tetrandra. Planta Med, 1991 Apr
(Abstract Available)
Li QM, et al. Mass spectral characterization of C-glycosidic flavonoids isolated from a medicinal plant (Passiflora incarnata). J Chromatogr, 1991 Jan 2
(Abstract Available)
Medina JH, et al. Chrysin (5,7-di-OH-flavone), a naturally-occurring ligand for benzodiazepine receptors, with anticonvulsant properties. Biochem Pharmacol, 1990 Nov 15
(Abstract Available)
Sopranzi N, et al. [Biological and electroencephalographic parameters in rats in relation to Passiflora incarnata L.] Clin Ter, 1990 Mar 15
(Abstract Available)
Menghini A, et al. TLC determination of flavonoid accumulation in clonal populations of Passiflora incarnata L. Pharmacol Res Commun, 1988 Dec
(Abstract Available)
Della Loggia R, et al. [Evaluation of the activity on the mouse CNS of several plant extracts and a combination of them] Riv Neurol, 1981 Sep-Oct
(Abstract Available)
Zúñiga Rojas J. [Oil seeds from the American tropics] Arch Latinoam Nutr, 1981 Jun
(Abstract Available)
Pietta P, et al. Isocratic liquid chromatographic method for the simultaneous determination of Passiflora incarnata L. and Crataegus monogyna flavonoids in drugs. J Chromatogr, 1986 Apr 23
Brand RJ, et al. Cloning, sequencing, and expression in Escherichia coli of the coat protein gene of a new potyvirus infection South African Passiflora. Arch Virol, 1993
Speroni E, et al. Neuropharmacological activity of extracts from Passiflora incarnata. Planta Med, 1988 Dec
Smith GW, et al. Vasculitis associated with herbal preparation containing Passiflora extract [letter] Br J Rheumatol, 1993 Jan
Buchbauer G, et al. Passiflora and lime-blossoms: motility effects after inhalation of the essential oils and of some of the main constituents in animal experiment. Arch Pharm (Weinheim), 1992 Apr
Spencer KC, et al. Cyanogenesis of Passiflora edulis. J Agric Food Chem, 1983 Jul-Aug
Oga S, et al. Pharmacological trials of crude extract of Passiflora alata. Planta Med, 1984 Aug
Lutomski J, et al. [Pharmacological investigations on raw materials of the genus passiflora. 4. The comparsion of contents of alkaloids in some harman raw materials (author's transl)] Planta Med, 1975 Jun
Lutomski J, et al. [Pharmacochemical investigations on raw materials genus passiflora. 3. Phytochemical investigations on raw materials of passiflora edulis forma flavicarpa (author's transl)] Planta Med, 1975 May
Lutomski J, et al. Pharmacochemical investigations of the raw materials from passiflora genus. 2. The pharmacochemical estimation of juices from the fruits of Passiflora edulis and Passiflora edulis forma flavicarpa. Planta Med, 1975 Mar
Lutomski J, et al. [Pharmacochemical investigation of the raw materials from passiflora genus. 1. New method of chromatographic separation and fluorometric-planimetric determination of alkaloids and flavonoids in harman raw materials (author's transl)] Planta Med, 1974 Dec
Aoyagi N, et al. Studies on passiflora incarnata dry extract. I. Isolation of maltol and pharmacological action of maltol and ethyl maltol. Chem Pharm Bull (Tokyo), 1974 May
Nicolls JM, et al. Passicol, an antibacterial and antifungal agent produced by Passiflora plant species: qualitative and quantitative range of activity. Antimicrob Agents Chemother, 1973 Jan
Birner J, et al. Passicol, an antibacterial and antifungal agent produced by Passiflora plant species: preparation and physicochemical characteristics. Antimicrob Agents Chemother,1973 Jan
Bennati E. [Quantitative determination of harmane and harmine in the extract of Passiflora incarnata] Boll Chim Farm, 1971 Nov
Bennati E, et al. [Gas chromatography of fluid extract of Passiflora incarnata] Boll Chim Farm, 1968 Nov
Glotzbach B, et al. [Flavenoids from Passiflora incarnata L., Passiflora quandrangularis L. and Passiflora pulchella H. B. V. A chromatographic study] Planta Med, 1968 Feb
Possible anxiolytic effects of chrysin, a central benzodiazepine receptor ligand isolated from Passiflora coerulea.
Wolfman C; Viola H; Paladini A; Dajas F; Medina JH
Instituto de Biología Celular, Facultad de Medicina, UBA, Argentina.
Pharmacol Biochem Behav, 47: 1, 1994 Jan, 1-4
Abstract
The pharmacological effects of 5,7-dihydroxyflavone (chrysin), a naturally occurring monoflavonoid that displaces [3H]flunitrazepam binding to the central benzodiazepine (BDZ) receptors, were examined in mice. In the elevated plus-maze test of anxiety, diazepam (DZ, 0.3-0.6 mg/kg) or chrysin (1 mg/kg) induced increases in the number of entries into the open arms and in the time spent on the open arms, consistent with an anxiolytic action of both compounds. The effects of chrysin on the elevated plus-maze was abolished by pretreatment with the specific BDZ receptor antagonist Ro 15-1788 (3 mg/kg). In the holeboard, diazepam (1 mg/kg) and chrysin (3 mg/kg) increased the time spent head-dipping. In contrast, high doses of DZ (6 mg/kg) but not of chrysin produced a decrease in the number of head dips and in the time spent head-dipping. In the horizontal wire test, diazepam (6 mg/kg) had a myorelaxant action. In contrast, chrysin (0.6-30 mg/kg) produced no effects in this test. These data suggest that chrysin possesses anxiolytic actions without inducing sedation and muscle relaxation. We postulate that this natural monoflavonoid is a partial agonist of the central BDZ receptors.
4-Hydroxy-2-cyclopentenone: an anti-Pseudomonas and cytotoxic component from Passiflora tetrandra.
Perry NB; Albertson GD; Blunt JW; Cole AL; Munro MH; Walker JR
Department of Chemistry, University of Canterbury, Christchurch, New Zealand.
Planta Med, 57: 2, 1991 Apr, 129-31
Abstract
4-Hydroxy-2-cyclopentenone is responsible for the anti-bacterial activity of an extract of leaves from Passiflora tetrandra with minimum inhibitory doses (MID) of ca. 10 micrograms/disk against Escherichia coli, Bacillus subtilis, and Pseudomonas aeruginosa. 4-Hydroxy-2-cyclopentenone is also cytotoxic to P388 murine leukemia cells (IC50 of less than 1 microgram/ml).
Mass spectral characterization of C-glycosidic flavonoids isolated from a medicinal plant (Passiflora incarnata).
Li QM; van den Heuvel H; Delorenzo O; Corthout J; Pieters LA; Vlietinck AJ; Claeys M
Department of Pharmaceutical Sciences, University of Antwerp (U.I.A.), Wilrijk-Antwerp, Belgium.
J Chromatogr, 562: 1-2, 1991 Jan 2, 435-46
Abstract
The four major C-glycosidic flavonoids isolated from Passiflora incarnata were identified as schaftoside, isoschaftoside, isovetexin-2''-O-glucopyranoside and isoorientin-2''-O-glucopyranoside on the basis of mass spectral and 13C NMR data. The daughter ion spectra of [M + H]+ ions of schaftoside and isoschaftoside showed differences for the [M + H - 104]+ ions, which could be rationalized by hydrogen bonding effects. In the negative-ion mode, pronounced differences were found for the [M - H - 90]- and [M - H - 120]- ions, formed by prevalent fragmentation in the C-6-linked sugar moiety. With respect to isovitexin-2''-O-beta-glucopyranoside and isoorientin-2''-O-beta-glucopyranoside, the daughter ion spectra of both the [M + H]+ and [M - H]- ions provided evidence for a 1----2 linkage in the diglucosidic moiety. Support for C-6 glucosylation was obtained by recording the daughter ion spectra of [M - H - 162]- ions, which were in good agreement with that obtained for [M - H]- ions of isovitexin.
Chrysin (5,7-di-OH-flavone), a naturally-occurring ligand for benzodiazepine receptors, with anticonvulsant properties.
Medina JH; Paladini AC; Wolfman C; Levi de Stein M; Calvo D; Diaz LE; Peña C
Instituto de Biología Celular, Facultad de Medicina, Buenos Aires, Argentina.
Biochem Pharmacol, 40: 10, 1990 Nov 15, 2227-31
Abstract
Chrysin (5,7-di-OH-flavone) was identified in Passiflora coerulea L., a plant used as a sedative in folkloric medicine. Chrysin was found to be a ligand for the benzodiazepine receptors, both central (Ki = 3 microM, competitive mechanism) and peripheral (Ki = 13 microM, mixed-type mechanism). Administered to mice by the intracerebroventricular route, chrysin was able to prevent the expression of tonic-clonic seizures induced by pentylenetertrazol. Ro 15-1788, a central benzodiazepine receptor antagonist, abolished this effect. In addition, all of the treated mice lose the normal righting reflex which suggests a myorelaxant action of the flavonoid. The presence in P. coerulea of benzodiazepine-like compounds was also confirmed.
[Biological and electroencephalographic parameters in rats in relation to Passiflora incarnata L.]
Sopranzi N; De Feo G; Mazzanti G; Tolu L
Istituto di Farmacologia Medica, Università degli Studi di Roma, La Sapienza.
Clin Ter, 132: 5, 1990 Mar 15, 329-33
Abstract
In this paper we have studied the rat under chronic treatment with Passiflora oral. For a three week period we have recorded, once a week, weight, rectal temperature, tail flick, motor coordination and general activity in a one-arm radial maze. At the end of the third week surface (SEEG) and deep (DEEG) EEG were recorded from treated animals. The findings are: 1) no change was observed in weight, rectal temperature, tail-flick and motor coordination. 2) The treated rats, when in a one-arm radial maze showed a diminished general activity. 3) SEEG and DEEG recordings showed "normal" electric activity.
TLC determination of flavonoid accumulation in clonal populations of Passiflora incarnata L.
Menghini A; Mancini LA
Department of Plant Biology, University of Perugia, Italy.
Pharmacol Res Commun, 20 Suppl 5:1988 Dec, 113-6
Abstract
Flavonoid production and accumulation during the ontogenic cycle of Passiflora incarnata L. was studied. The highest concentration of isovitexin occurred between pre-flowering and flowering stages. The greatest accumulation of flavonoids took place in the leaves. Furthermore some pharmacodiagnostic characteristics of the drug of P. incarnata were specified using a Scanning Electron Microscope.
[Evaluation of the activity on the mouse CNS of several plant extracts and a combination of them]
Della Loggia R; Tubaro A; Redaelli C
Riv Neurol, 51: 5, 1981 Sep-Oct, 297-310
Abstract
Some activities of seven vegetable extracts and an association of them given by oral route were tested on the C.N.S. of the mouse. Among these, Crataegus oxyacantha and, less clearly, Valeriana officinalis show some sedative activity, whereas the extract from Passiflora incarnata gives some anxiolytic effect. Matricaria chamomilla and Piscidia erythrina stand in an intermediate position between the previous ones. Hyoscyamus niger proved to be active in only one of the tests performed, whereas Atropa belladonna did not show any activity on the C.N.S. The association of the seven extracts seemed to act in a synergetic way, the resulting activity being sedative at high dosage and anxiolytic at low dosage.
[Oil seeds from the American tropics]
Zúñiga Rojas J
Arch Latinoam Nutr, 31: 2, 1981 Jun, 350-70
Abstract
The fatty acid composition of the oil content of seeds from native fruits of the American Tropics was analyzed. The species studied were maracuyá (Passiflora edulis), morro (Crescentia alata), zapote (Calocarpum mammosum) and icaco (Chrysobalanus icaco). The findings for maracuyá are in agreement with the data found in the literature. There is no information pertaining to the fatty acid composition of the seed oil for the other species. Icaco oil showed 4 unusual signals in its GC profile, two of which were identified as geometric isomers of licanic acid. The structure of parinaric acid was assigned to the second pair.
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